Literature DB >> 28292942

The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease.

Courtney Lane-Donovan1, Joachim Herz2,3.   

Abstract

The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer's disease has focused attention on the role this receptor family plays in the CNS. Surprisingly, it was discovered that two LDLR family members, ApoE receptor 2 (Apoer2) and VLDL receptor (Vldlr), play key roles in brain development and adult synaptic plasticity, primarily by mediating Reelin signaling. This review focuses on Apoer2 and Vldlr signaling in the CNS and its role in human disease.
Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  Alzheimer’s disease; apolipoprotein E; apolipoprotein E receptor 2; apolipoproteins; cell signaling; endocytosis; lipoprotein receptors; neurons; very low density lipoprotein receptor

Mesh：

Substances：

Year:  2017        PMID： 28292942      PMCID： PMC5454520          DOI： 10.1194/jlr.R075507

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  87 in total

1.  Reelin binds alpha3beta1 integrin and inhibits neuronal migration.

Authors:  L Dulabon; E C Olson; M G Taglienti; S Eisenhuth; B McGrath; C A Walsh; J A Kreidberg; E S Anton
Journal:  Neuron       Date:  2000-07       Impact factor: 17.173

2.  Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration.

Authors:  Raymond F Burk; Kristina E Hill; Amy K Motley; Virginia P Winfrey; Suguru Kurokawa; Stuart L Mitchell; Wanqi Zhang
Journal:  FASEB J       Date:  2014-04-23       Impact factor: 5.191

3.  Reelin modulates NMDA receptor activity in cortical neurons.

Authors:  Ying Chen; Uwe Beffert; Mert Ertunc; Tie-Shan Tang; Ege T Kavalali; Ilya Bezprozvanny; Joachim Herz
Journal:  J Neurosci       Date:  2005-09-07       Impact factor: 6.167

Review 4.  Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

Authors:  Robert W Mahley; Karl H Weisgraber; Yadong Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-27       Impact factor: 11.205

5.  Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta.

Authors:  Uwe Beffert; Gerardo Morfini; Hans H Bock; Huichuan Reyna; Scott T Brady; Joachim Herz
Journal:  J Biol Chem       Date:  2002-10-09       Impact factor: 5.157

6.  Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.

Authors:  Aycan Sentürk; Sylvia Pfennig; Alexander Weiss; Katja Burk; Amparo Acker-Palmer
Journal:  Nature       Date:  2011-04-03       Impact factor: 49.962

7.  Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice.

Authors:  M Sheldon; D S Rice; G D'Arcangelo; H Yoneshima; K Nakajima; K Mikoshiba; B W Howell; J A Cooper; D Goldowitz; T Curran
Journal:  Nature       Date:  1997-10-16       Impact factor: 49.962

8.  Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration.

Authors:  Sophia M Blake; Vera Strasser; Nuno Andrade; Sarah Duit; Reinhold Hofbauer; Wolfgang J Schneider; Johannes Nimpf
Journal:  EMBO J       Date:  2008-10-23       Impact factor: 11.598

9.  Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease.

Authors:  Lluís Pujadas; Daniela Rossi; Rosa Andrés; Cátia M Teixeira; Bernat Serra-Vidal; Antoni Parcerisas; Rafael Maldonado; Ernest Giralt; Natàlia Carulla; Eduardo Soriano
Journal:  Nat Commun       Date:  2014-03-06       Impact factor: 14.919

10.  Reelin activates SRC family tyrosine kinases in neurons.

Authors:  Hans H Bock; Joachim Herz
Journal:  Curr Biol       Date:  2003-01-08       Impact factor: 10.834
View more
  26 in total

Review 1.  APOE in the normal brain.

Authors:  Sarah A Flowers; G William Rebeck
Journal:  Neurobiol Dis       Date:  2020-01-03       Impact factor: 5.996

Review 2.  Cellular cholesterol homeostasis and Alzheimer's disease.

Authors:  Ta-Yuan Chang; Yoshio Yamauchi; Mazahir T Hasan; Catherine Chang
Journal:  J Lipid Res       Date:  2017-03-15       Impact factor: 5.922

Review 3.  ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease.

Authors:  Yonghe Li; Jesse R Macyczko; Chia-Chen Liu; Guojun Bu
Journal:  Neurobiol Aging       Date:  2022-03-22       Impact factor: 5.133

4.  The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex.

Authors:  Himari Ogino; Tsuzumi Nakajima; Yuki Hirota; Kohki Toriuchi; Mineyoshi Aoyama; Kazunori Nakajima; Mitsuharu Hattori
Journal:  J Neurosci       Date:  2020-09-10       Impact factor: 6.167

5.  Nonhuman Primate Models of Neurodegenerative Disorders.

Authors:  Marina E Emborg
Journal:  ILAR J       Date:  2017-12-01

6.  Reelin Improves Cognition and Extends the Lifespan of Mutant Ndel1 Mice with Postnatal CA1 Hippocampus Deterioration.

Authors:  Ivana Kiroski; Yulan Jiang; Cezar Gavrilovici; Fan Gao; Sukyoung Lee; Morris H Scantlebury; Milene Vandal; Sang Ki Park; Li-Huei Tsai; G Campbell Teskey; Jong M Rho; Minh Dang Nguyen
Journal:  Cereb Cortex       Date:  2020-07-30       Impact factor: 5.357

7.  miR-30b-5p inhibits cancer progression and enhances cisplatin sensitivity in lung cancer through targeting LRP8.

Authors:  Haitao Qiu; Xiaokang Shen; Bing Chen; Tianming Chen; Guodong Feng; Shilin Chen; Dongjie Feng; Qiaoshu Xu
Journal:  Apoptosis       Date:  2021-03-29       Impact factor: 4.677

8.  Multi-Dimensional Transcriptome Analysis Reveals Modulation of Cholesterol Metabolism as Highly Integrated Response to Brain Injury.

Authors:  Victor Gourain; Olivier Armant; Luisa Lübke; Nicolas Diotel; Sepand Rastegar; Uwe Strähle
Journal:  Front Neurosci       Date:  2021-05-14       Impact factor: 4.677

Review 9.  Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.

Authors:  Yu Yamazaki; Na Zhao; Thomas R Caulfield; Chia-Chen Liu; Guojun Bu
Journal:  Nat Rev Neurol       Date:  2019-07-31       Impact factor: 44.711

10.  Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes.

Authors:  Laurent Calvier; Xunde Xian; Richard G Lee; Anastasia Sacharidou; Chieko Mineo; Philip W Shaul; Maria Z Kounnas; Shirling Tsai; Joachim Herz
Journal:  Arterioscler Thromb Vasc Biol       Date:  2021-02-25       Impact factor: 10.514
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.