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Literature DB >> 28292700

Canonical and noncanonical functions of ULK/Atg1.

Abstract

Mammalian Unc-51-like kinases 1 and 2 (ULK1 and ULK2) belong to the ULK/Atg1 family of serine/threonine kinases, which are conserved from yeast to mammals. Although ULK/Atg1 is best known for regulating flux through the autophagy pathway, it has evolutionarily conserved noncanonical functions in protein trafficking that are essential for maintaining cellular homeostasis. As a direct target of energy- and nutrient-sensing kinases, ULK/Atg1 is positioned to regulate the distribution and use of cellular resources in response to metabolic cues. In this review, we provide an overview of the molecular mechanisms through which ULK/Atg1 carries out its canonical and noncanonical functions and the signaling pathways that link its function to metabolism. We also highlight potential contributions of ULK/Atg1 in human diseases, including cancer and neurodegeneration.

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Year: 2017 PMID： 28292700 PMCID： PMC5678971 DOI： 10.1016/j.ceb.2017.02.011

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

84 in total

1. The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics.

Authors: L Chen; H Wang; S Vicini; R W Olsen
Journal: Proc Natl Acad Sci U S A Date: 2000-10-10 Impact factor: 11.205

2. Intensive expression of UNC-51-like kinase 1 is a novel biomarker of poor prognosis in patients with esophageal squamous cell carcinoma.

Authors: Shan Jiang; Yong Li; Ying-Hui Zhu; Xiao-Qi Wu; Jun Tang; Zheng Li; Gong-Kan Feng; Rong Deng; Dan-Dan Li; Rong-Zhen Luo; Mei-Fang Zhang; Wei Qin; Xin Wang; Wei-Hua Jia; Xiao-Feng Zhu
Journal: Cancer Sci Date: 2011-05-31 Impact factor: 6.716

3. NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals.

Authors: Jean-Dominique Delcroix; Janice S Valletta; Chengbiao Wu; Stephen J Hunt; Anthony S Kowal; William C Mobley
Journal: Neuron Date: 2003-07-03 Impact factor: 17.173

4. Mitochondria regulate autophagy by conserved signalling pathways.

Authors: Martin Graef; Jodi Nunnari
Journal: EMBO J Date: 2011-04-05 Impact factor: 11.598

5. Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.

Authors: Xiang Zhou; J Ramesh Babu; Susana da Silva; Qing Shu; Isabella A Graef; Tim Oliver; Toshifumi Tomoda; Tomomi Tani; Marie W Wooten; Fan Wang
Journal: Proc Natl Acad Sci U S A Date: 2007-03-26 Impact factor: 11.205

6. UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly.

Authors: Hirofumi Toda; Hiroaki Mochizuki; Rafael Flores; Rebecca Josowitz; Tatiana B Krasieva; Vickie J Lamorte; Emiko Suzuki; Joseph G Gindhart; Katsuo Furukubo-Tokunaga; Toshifumi Tomoda
Journal: Genes Dev Date: 2008-12-01 Impact factor: 11.361

7. Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients.

Authors: Jun Tang; Rong Deng; Rong-Zhen Luo; Guo-Ping Shen; Mu-Yan Cai; Zi-Ming Du; Shan Jiang; Ming-Tian Yang; Jian-Hua Fu; Xiao-Feng Zhu
Journal: Breast Cancer Res Treat Date: 2012-05-15 Impact factor: 4.872

8. UNC51-like kinase 1 as a potential prognostic biomarker for hepatocellular carcinoma.

Authors: Hongtao Xu; Hong Yu; Xiaoyan Zhang; Xiaoying Shen; Kehao Zhang; Haihui Sheng; Shengbin Dai; Hengjun Gao
Journal: Int J Clin Exp Pathol Date: 2013-03-15

9. ER exit sites are physical and functional core autophagosome biogenesis components.

Authors: Martin Graef; Jonathan R Friedman; Christopher Graham; Mohan Babu; Jodi Nunnari
Journal: Mol Biol Cell Date: 2013-07-31 Impact factor: 4.138

10. Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death.

Authors: W Gao; Z Shen; L Shang; X Wang
Journal: Cell Death Differ Date: 2011-04-08 Impact factor: 15.828

30 in total

1. ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.

Authors: Bo Wang; Brian A Maxwell; Joung Hyuck Joo; Youngdae Gwon; James Messing; Ashutosh Mishra; Timothy I Shaw; Amber L Ward; Honghu Quan; Sadie Miki Sakurada; Shondra M Pruett-Miller; Tulio Bertorini; Peter Vogel; Hong Joo Kim; Junmin Peng; J Paul Taylor; Mondira Kundu
Journal: Mol Cell Date: 2019-04-09 Impact factor: 17.970

Review 2. Interferon signaling in cancer. Non-canonical pathways and control of intracellular immune checkpoints.

Authors: Diana Saleiro; Leonidas C Platanias
Journal: Semin Immunol Date: 2019-06 Impact factor: 11.130

3. MAPK15 is part of the ULK complex and controls its activity to regulate early phases of the autophagic process.

Authors: David Colecchia; Francesca Dapporto; Serena Tronnolone; Laura Salvini; Mario Chiariello
Journal: J Biol Chem Date: 2018-08-21 Impact factor: 5.157

4. Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation.

Authors: Lauren K Tyra; Nilay Nandi; Charles Tracy; Helmut Krämer
Journal: Dev Cell Date: 2020-02-06 Impact factor: 12.270

5. The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.

Authors: Bo Wang; Rekha Iyengar; Xiujie Li-Harms; Joung Hyuck Joo; Christopher Wright; Alfonso Lavado; Linda Horner; Mao Yang; Jun-Lin Guan; Sharon Frase; Douglas R Green; Xinwei Cao; Mondira Kundu
Journal: Autophagy Date: 2017-12-24 Impact factor: 16.016

Review 6. Circumventing autophagy inhibition.

Authors: Christina G Towers; Andrew Thorburn
Journal: Cell Cycle Date: 2019-11-18 Impact factor: 4.534

7. The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia.

Authors: Christophe Lechauve; Julia Keith; Eugene Khandros; Stephanie Fowler; Kalin Mayberry; Abdullah Freiwan; Christopher S Thom; Paola Delbini; Emilio Boada Romero; Jingjing Zhang; Irene Motta; Heather Tillman; M Domenica Cappellini; Mondira Kundu; Mitchell J Weiss
Journal: Sci Transl Med Date: 2019-08-21 Impact factor: 17.956