Tani Chiara 1 , Carli Linda 1 , Delle Sedie Andrea 1 , Riente Lucrezia 1 , Vagnani Sabrina 1 , Talarico Rosaria 1 , Della Rossa Alessandra 1 , Baldini Chiara 1 , Bombardieri Stefano 1 , Mosca Marta 1 Show Affiliations »
Abstract
OBJECTIVE: Joint involvement is common among patients with systemic lupus erythematosus (SLE). Aim of this work was to evaluate the correlation between the presence of joint involvement and patient-reported pain, perception of disease activity, general health and quality of life. METHODS: Fifty consecutive SLE patients were enrolled in the study. All patients underwent a complete clinical evaluation including a 44-joint count; in addition, an ultrasound evaluation of joint involvement of hands and wrists was performed. The following patients reported outcomes (PROs) were completed: Visual Analog Scales 0-100 mm (VAS) evaluating patients reported pain, patient's perception of global disease activity and general health (GH) and a validated Italian version of the Health Assessment Questionnaire (HAQ). RESULTS: Fourteen patients (28%) reported a significant morning stiffness lasting for more than 30 minutes; hand or wrist arthritis was clinically detectable in 10 (20%) patients, while the US evaluation exhibited at least one joint or tendon pathology in 18 patients (36%). The mean VAS score for pain and disease activity perception was 27 (±27.7) mm and 25.3 (±25.2) mm, respectively, the mean of GH score was 33.2 (±24.3) mm, and the mean HAQ score was 0.34 (±0.5). A significant correlation was observed between VAS score for pain, patient's perception of disease activity and GH and the presence of arthritis. CONCLUSION: PROs may play an important role in guiding therapeutic decisions and suggest the utility of ultrasound evaluation in patients reporting articular symptoms. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
OBJECTIVE: Joint involvement is common among patients with systemic lupus erythematosus (SLE ). Aim of this work was to evaluate the correlation between the presence of joint involvement and patient -reported pain , perception of disease activity, general health and quality of life. METHODS: Fifty consecutive SLE patients were enrolled in the study. All patients underwent a complete clinical evaluation including a 44-joint count; in addition, an ultrasound evaluation of joint involvement of hands and wrists was performed. The following patients reported outcomes (PROs) were completed: Visual Analog Scales 0-100 mm (VAS) evaluating patients reported pain , patient 's perception of global disease activity and general health (GH) and a validated Italian version of the Health Assessment Questionnaire (HAQ). RESULTS: Fourteen patients (28%) reported a significant morning stiffness lasting for more than 30 minutes; hand or wrist arthritis was clinically detectable in 10 (20%) patients , while the US evaluation exhibited at least one joint or tendon pathology in 18 patients (36%). The mean VAS score for pain and disease activity perception was 27 (±27.7) mm and 25.3 (±25.2) mm, respectively, the mean of GH score was 33.2 (±24.3) mm, and the mean HAQ score was 0.34 (±0.5). A significant correlation was observed between VAS score for pain , patient 's perception of disease activity and GH and the presence of arthritis . CONCLUSION: PROs may play an important role in guiding therapeutic decisions and suggest the utility of ultrasound evaluation in patients reporting articular symptoms. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Disease
Species
Keywords:
Patient reported outcomes; SLE; burden of disease; joint involvement; therapeutic decisions; ultrasound evaluation.
Mesh： See more »
Year: 2018
PMID： 28292254 DOI： 10.2174/1573397113666170314110022
Source DB: PubMed Journal: Curr Rheumatol Rev ISSN： 1573-3971