Literature DB >> 2829125

Hitch-hiking from HRAS1 to the WAGR locus with CMGT markers.

W Bickmore1, S Christie, V van Heyningen, N D Hastie, D J Porteous.   

Abstract

The clinical association of Wilms' tumour with aniridia, genitourinary abnormalities and mental retardation (WAGR syndrome) is characterised cytogenetically by variable length, constitutional deletion of the short arm of chromosome 11, which always includes at least part of band 11p13. HRAS1-selected chromosome mediated gene transfer (CMGT) generated a transformant, E65-6, in which the only human genes retained map either to band 11p13 or, with HRAS1, in the region 11p15.4-pter. Human recombinants isolated from E65-6 were mapped to a panel of five WAGR deletion hybrids and two clinically related translocations. We show that E65-6 is enriched congruent to 400-fold for 11p15.4-pter markers and congruent to 200-fold for 11p13 markers. 'Hitch-hiking' from HRAS1 with CMGT markers has allowed us to define seven discrete intervals which subtend band 11p13. Both associated translocations co-locate within the smallest region of overlap for the WAGR locus, which has been redefined by identifying a new interval closer than FSHB.

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Mesh：

Year:  1988        PMID： 2829125      PMCID： PMC334612          DOI： 10.1093/nar/16.1.51

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  18 in total

1.  Construction of linkage maps with DNA markers for human chromosomes.

Authors:  R White; M Leppert; D T Bishop; D Barker; J Berkowitz; C Brown; P Callahan; T Holm; L Jerominski
Journal:  Nature       Date:  1985 Jan 10-18       Impact factor: 49.962

2.  Investigation of chromosome-mediated gene transfer using the HPRT region of the human X chromosome as a model.

Authors:  C A Pritchard; P N Goodfellow
Journal:  Genes Dev       Date:  1987-04       Impact factor: 11.361

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Journal:  Cytogenet Cell Genet       Date:  1982

4.  Eucaryotic chromosome transfer: production of a murine-specific cosmid library from a neor-linked fragment of murine chromosome 17.

Authors:  J H Weis; J G Seidman; D E Housman; D L Nelson
Journal:  Mol Cell Biol       Date:  1986-02       Impact factor: 4.272

5.  Molecular analysis of chromosome 11 deletions in aniridia-Wilms tumor syndrome.

Authors:  V van Heyningen; P A Boyd; A Seawright; J M Fletcher; J A Fantes; K E Buckton; G Spowart; D J Porteous; R E Hill; M S Newton
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

6.  Gene mapping and physical arrangements of human chromatin in transformed, hybrid cells: fluorescent and autoradiographic in situ hybridization compared.

Authors:  A R Mitchell; P Ambros; J R Gosden; J E Morten; D J Porteous
Journal:  Somat Cell Mol Genet       Date:  1986-07

7.  The beta-subunit of follicle-stimulating hormone is deleted in patients with aniridia and Wilms' tumour, allowing a further definition of the WAGR locus.

Authors:  T Glaser; W H Lewis; G A Bruns; P C Watkins; C E Rogler; T B Shows; V E Powers; H F Willard; J M Goguen; K O Simola
Journal:  Nature       Date:  1986 Jun 26-Jul 2       Impact factor: 49.962

8.  Specific cloning of DNA fragments absent from the DNA of a male patient with an X chromosome deletion.

Authors:  L M Kunkel; A P Monaco; W Middlesworth; H D Ochs; S A Latt
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

9.  Familial aniridia and translocation t(4;11)(q22;p13) without Wilms' tumor.

Authors:  K O Simola; S Knuutila; I Kaitila; A Pirkola; P Pohja
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

10.  Cloning of a representative genomic library of the human X chromosome after sorting by flow cytometry.

Authors:  K E Davies; B D Young; R G Elles; M E Hill; R Williamson
Journal:  Nature       Date:  1981-10-01       Impact factor: 49.962
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  8 in total

Review 1.  Mouse chromosome 2.

Authors:  L D Siracusa; C M Abbott
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

2.  Somatic cell hybrid and long-range physical mapping of 11p13 microdissected genomic clones.

Authors:  L M Davis; G Senger; H J Lüdecke; U Claussen; B Horsthemke; S S Zhang; B Metzroth; K Hohenfellner; B Zabel; T B Shows
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

3.  A deletion map of the WAGR region on chromosome 11.

Authors:  M Gessler; G H Thomas; P Couillin; C Junien; B C McGillivray; M Hayden; G Jaschek; G A Bruns
Journal:  Am J Hum Genet       Date:  1989-04       Impact factor: 11.025

4.  Rapid isolation of moderate and highly polymorphic DNA fragments mapping close to WT (Wilms' tumour) and AN2 (aniridia) on chromosome 11.

Authors:  P A Boyd; S Christie; N D Hastie; D J Porteous
Journal:  Hum Genet       Date:  1989-03       Impact factor: 4.132

5.  The aniridia-Wilms' tumour association: molecular and genetic analysis of chromosome deletions on the short arm of chromosome 11.

Authors:  J K Cowell; R B Wadey; B B Buckle; J Pritchard
Journal:  Hum Genet       Date:  1989-05       Impact factor: 4.132

6.  Interspecific backcross mice show sex-specific differences in allelic inheritance.

Authors:  L D Siracusa; W G Alvord; W A Bickmore; N A Jenkins; N G Copeland
Journal:  Genetics       Date:  1991-08       Impact factor: 4.562

7.  Role for the Wilms tumor gene in genital development?

Authors:  V van Heyningen; W A Bickmore; A Seawright; J M Fletcher; J Maule; G Fekete; M Gessler; G A Bruns; C Huerre-Jeanpierre; C Junien
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205

8.  Submicroscopic deletions at the WAGR locus, revealed by nonradioactive in situ hybridization.

Authors:  J A Fantes; W A Bickmore; J M Fletcher; F Ballesta; I M Hanson; V van Heyningen
Journal:  Am J Hum Genet       Date:  1992-12       Impact factor: 11.025
  8 in total

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