Ana L Rocha1, Erica L Vieira2, Márcia C Ferreira1, Laura M Maia1, Antonio L Teixeira2,3, Fernando M Reis1. 1. Department of Obstetrics & Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 2. Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 3. Department of Psychiatry & Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Abstract
AIM: To test whether plasma BDNF levels are useful to predict the presence of endometriosis in women with pelvic pain. PATIENTS & METHODS: Prospective cross-sectional study including 67 consecutive women aged 24-49 years, scheduled for laparoscopy due to chronic pelvic pain. Preoperative plasma samples were assayed for BDNF using a commercial enzyme immunoassay. RESULTS: Women with ovarian endometrioma had higher preoperative plasma BDNF (1063 ± 157 pg/ml) compared with women with other benign ovarian tumors (537 ± 131 pg/ml, F = 2.53; p = 0.02). However, plasma BDNF levels were not helpful to indicate the presence of peritoneal or deep infiltrating endometriosis. Plasma BDNF levels were positively correlated with the severity of pelvic pain (r = 0.489; p < 0.0001). CONCLUSION: Plasma BDNF might be a biomarker of ovarian endometrioma but not a useful diagnostic marker to detect other forms of endometriosis in women with painful symptoms.
AIM: To test whether plasma BDNF levels are useful to predict the presence of endometriosis in women with pelvic pain. PATIENTS & METHODS: Prospective cross-sectional study including 67 consecutive women aged 24-49 years, scheduled for laparoscopy due to chronic pelvic pain. Preoperative plasma samples were assayed for BDNF using a commercial enzyme immunoassay. RESULTS:Women with ovarian endometrioma had higher preoperative plasma BDNF (1063 ± 157 pg/ml) compared with women with other benign ovarian tumors (537 ± 131 pg/ml, F = 2.53; p = 0.02). However, plasma BDNF levels were not helpful to indicate the presence of peritoneal or deep infiltrating endometriosis. Plasma BDNF levels were positively correlated with the severity of pelvic pain (r = 0.489; p < 0.0001). CONCLUSION: Plasma BDNF might be a biomarker of ovarian endometrioma but not a useful diagnostic marker to detect other forms of endometriosis in women with painful symptoms.
Authors: Jie Yu; Antônio M C Francisco; Bansari G Patel; J Mark Cline; Eric Zou; Sarah L Berga; Robert N Taylor Journal: Am J Pathol Date: 2018-07-20 Impact factor: 4.307
Authors: Setor K Sorkpor; Kelli Galle; Antonio L Teixeira; Gabriela D Colpo; Brian Ahn; Natalie Jackson; Hongyu Miao; Hyochol Ahn Journal: Biol Res Nurs Date: 2021-04-29 Impact factor: 2.318
Authors: Jocelyn M Wessels; Ravi K Agarwal; Aamer Somani; Chris P Verschoor; Sanjay K Agarwal; Warren G Foster Journal: Sci Rep Date: 2020-11-19 Impact factor: 4.379