Danielle Barnes1, K T Park2. 1. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Naval Medical Center San Diego, San Diego, CA, USA. danimhbarnes@gmail.com. 2. Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Stanford Children's Health, Palo Alto, CA, USA.
Abstract
PURPOSE OF REVIEW: Tremendous acceleration has been made in understanding the gut microbiota in the past decade and, with it, further understanding of the pathologic role of dysbiosis and the use of fecal microbiota transplantation (FMT) as therapy. FMT has been studied in many disease states including the most common indication of Clostridium difficile infection (CDI), though many questions regarding stool donor selection remain. RECENT FINDINGS: Though traditionally, one donor has provided stool for one patient, research is underway to explore many donor selection considerations from the use of pooled donor stool to selection of a high diversity donor. It is well-known that dietary intake shapes the gut microbiota and the potential implications of this on FMT donor selection are being explored. Though further high-quality research is needed, optimizing the fecal microbiota inoculum holds great promise.
PURPOSE OF REVIEW: Tremendous acceleration has been made in understanding the gut microbiota in the past decade and, with it, further understanding of the pathologic role of dysbiosis and the use of fecal microbiota transplantation (FMT) as therapy. FMT has been studied in many disease states including the most common indication of Clostridium difficileinfection (CDI), though many questions regarding stool donor selection remain. RECENT FINDINGS: Though traditionally, one donor has provided stool for one patient, research is underway to explore many donor selection considerations from the use of pooled donor stool to selection of a high diversity donor. It is well-known that dietary intake shapes the gut microbiota and the potential implications of this on FMT donor selection are being explored. Though further high-quality research is needed, optimizing the fecal microbiota inoculum holds great promise.
Authors: Anne Vrieze; Els Van Nood; Frits Holleman; Jarkko Salojärvi; Ruud S Kootte; Joep F W M Bartelsman; Geesje M Dallinga-Thie; Mariette T Ackermans; Mireille J Serlie; Raish Oozeer; Muriel Derrien; Anne Druesne; Johan E T Van Hylckama Vlieg; Vincent W Bloks; Albert K Groen; Hans G H J Heilig; Erwin G Zoetendal; Erik S Stroes; Willem M de Vos; Joost B L Hoekstra; Max Nieuwdorp Journal: Gastroenterology Date: 2012-06-20 Impact factor: 22.682
Authors: Carlotta De Filippo; Duccio Cavalieri; Monica Di Paola; Matteo Ramazzotti; Jean Baptiste Poullet; Sebastien Massart; Silvia Collini; Giuseppe Pieraccini; Paolo Lionetti Journal: Proc Natl Acad Sci U S A Date: 2010-08-02 Impact factor: 11.205
Authors: Paul Moayyedi; Michael G Surette; Peter T Kim; Josie Libertucci; Melanie Wolfe; Catherine Onischi; David Armstrong; John K Marshall; Zain Kassam; Walter Reinisch; Christine H Lee Journal: Gastroenterology Date: 2015-04-07 Impact factor: 22.682
Authors: Ilan Youngster; George H Russell; Christina Pindar; Tomer Ziv-Baran; Jenny Sauk; Elizabeth L Hohmann Journal: JAMA Date: 2014-11-05 Impact factor: 56.272
Authors: Els van Nood; Anne Vrieze; Max Nieuwdorp; Susana Fuentes; Erwin G Zoetendal; Willem M de Vos; Caroline E Visser; Ed J Kuijper; Joep F W M Bartelsman; Jan G P Tijssen; Peter Speelman; Marcel G W Dijkgraaf; Josbert J Keller Journal: N Engl J Med Date: 2013-01-16 Impact factor: 91.245
Authors: Colleen R Kelly; Alexander Khoruts; Christopher Staley; Michael J Sadowsky; Mortadha Abd; Mustafa Alani; Brianna Bakow; Patrizia Curran; Joyce McKenney; Allison Tisch; Steven E Reinert; Jason T Machan; Lawrence J Brandt Journal: Ann Intern Med Date: 2016-08-23 Impact factor: 25.391
Authors: Ilan Youngster; Jasmin Mahabamunuge; Hannah K Systrom; Jenny Sauk; Hamed Khalili; Joanne Levin; Jess L Kaplan; Elizabeth L Hohmann Journal: BMC Med Date: 2016-09-09 Impact factor: 8.775
Authors: Mehrbod Estaki; Jason Pither; Peter Baumeister; Jonathan P Little; Sandeep K Gill; Sanjoy Ghosh; Zahra Ahmadi-Vand; Katelyn R Marsden; Deanna L Gibson Journal: Microbiome Date: 2016-08-08 Impact factor: 14.650
Authors: Abigail R Basson; Yibing Zhou; Brian Seo; Alexander Rodriguez-Palacios; Fabio Cominelli Journal: Transl Res Date: 2020-06-22 Impact factor: 7.012
Authors: Yuk Kam Yau; Wing Yan Joyce Mak; Nok Shun Rashid Lui; Wai Yin Rita Ng; Choi Yan Kitty Cheung; Ying Lee Amy Li; Yuet Ling Jessica Ching; Miu Ling Chin; Ho Shing Louis Lau; Ka Leung Francis Chan; Kay Sheung Paul Chan; Siew Chien Ng Journal: United European Gastroenterol J Date: 2021-10-08 Impact factor: 4.623
Authors: Emma K A Schmidt; Pamela J F Raposo; Karen L Madsen; Keith K Fenrich; Gillian Kabarchuk; Karim Fouad Journal: Biology (Basel) Date: 2021-03-24