Literature DB >> 2828947

Decatenation of kinetoplast DNA by an ATP-dependent DNA topoisomerase from the kinetoplast hemoflagellate Leishmania donovani.

A K Chakraborty1, H K Majumder.   

Abstract

An enzyme from Leishmania donovani that decatenates kinetoplast DNA networks into covalently closed monomeric circles has been isolated and characterized. The enzyme also relaxes supercoiled plasmid pBR322. The decatenation and relaxation reactions both require ATP and Mg2+. In both reactions the formation of topological isomers of unique linking numbers suggests that the enzyme is a type II DNA topoisomerase. Both the relaxation and decatenating activities are inhibited by novobiocin at a very high concentration.

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Year:  1987        PMID： 2828947     DOI： 10.1016/0166-6851(87)90074-0

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  10 in total

1.  The effect of topoisomerase II inhibitors on the kinetoplast ultrastructure.

Authors:  Danielle P Cavalcanti; Stênio P Fragoso; Samuel Goldenberg; Wanderley de Souza; Maria Cristina M Motta
Journal:  Parasitol Res       Date:  2004-10-28       Impact factor: 2.289

2.  Characterisation of the gene encoding type II DNA topoisomerase from Leishmania donovani: a key molecular target in antileishmanial therapy.

Authors:  A Das; A Dasgupta; S Sharma; M Ghosh; T Sengupta; S Bandopadhyay; H K Majumder
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

3.  Trypanosoma cruzi proliferation and differentiation are blocked by topoisomerase II inhibitors.

Authors:  M Gonzales-Perdomo; S L de Castro; M N Meirelles; S Goldenberg
Journal:  Antimicrob Agents Chemother       Date:  1990-09       Impact factor: 5.191

4.  Evolutionary History of TOPIIA Topoisomerases in Animals.

Authors:  Filipa Moreira; Miguel Arenas; Arnaldo Videira; Filipe Pereira
Journal:  J Mol Evol       Date:  2022-02-14       Impact factor: 2.395

5.  Effect of mitonafide analogs on topoisomerase II of Leishmania chagasi.

Authors:  K M Slunt; J M Grace; T L Macdonald; R D Pearson
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

6.  Kinetoplast-associated DNA topoisomerase in Crithidia fasciculata: crosslinking of mitochondrial topoisomerase II to both minicircles and maxicircles in cells treated with the topoisomerase inhibitor VP16.

Authors:  D S Ray; J C Hines; M Anderson
Journal:  Nucleic Acids Res       Date:  1992-07-11       Impact factor: 16.971

7.  Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II: implications in antileishmanial therapy.

Authors:  Arnab Roy Chowdhury; Suparna Mandal; Anindya Goswami; Monidipa Ghosh; Labanya Mandal; Debabani Chakraborty; Agneyo Ganguly; Gayatri Tripathi; Sibabrata Mukhopadhyay; Santu Bandyopadhyay; Hemanta K Majumder
Journal:  Mol Med       Date:  2003 Jan-Feb       Impact factor: 6.354

8.  Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania.

Authors:  A L Bodley; T A Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-25       Impact factor: 11.205

9.  Functional dissection of the C-terminal domain of type II DNA topoisomerase from the kinetoplastid hemoflagellate Leishmania donovani.

Authors:  Tanushri Sengupta; Mandira Mukherjee; Chhabinath Mandal; Aditi Das; Hemanta K Majumder
Journal:  Nucleic Acids Res       Date:  2003-09-15       Impact factor: 16.971

Review 10.  Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery.

Authors:  Rafael Balaña-Fouce; Raquel Alvarez-Velilla; Christopher Fernández-Prada; Carlos García-Estrada; Rosa M Reguera
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2014-08-24       Impact factor: 4.077
  10 in total

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