SgrT, a Small Protein That Packs a Sweet Punch.

The SgrS small RNA (sRNA) has been shown to protect against elevated levels of glucose phosphate by regulating the stability and translation of mRNAs encoding proteins involved in sugar transport and catabolism. The sRNA also was known to encode a protective 43-amino-acid protein, SgrT, but little was known about its mechanism of action. Lloyd et al. (J Bacteriol 199:e00869-16, 2017, https://doi.org/10.1128/JB.00869-16) use cell biological and genetic approaches to demonstrate that the small protein interacts with the PtsG importer to block glucose transport by this phosphotransferase system and promote utilization of nonpreferred carbon sources to maintain growth during glucose-phosphate stress.