Literature DB >> 2828898

Antibody reactivity with Skinner HSV vaccine.

E M Muniu1, J Durham, D Shariff, C E Hartley, A Fuller, J Melling, C Wiblin, G Wilkins, A Buchan, G R Skinner.   

Abstract

Antibody reactivity against herpes simplex virus (HSV) was investigated in 15 subjects who received three subcutaneous immunisations with Skinner HSV vaccine. Humoral antibody responses were detected against type 1 HSV in every subject and against type 2 HSV in all but one subject; immuno-precipitating antibody responses were infrequently detected. There was no antibody reactivity against host-cell (MRC-5), foetal calf serum or rubella virus antigen. None of the vaccinated subjects developed clinical evidence of herpes genitalis.

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Year:  1987        PMID： 2828898     DOI： 10.1007/BF00194891

Source DB:  PubMed          Journal:  Med Microbiol Immunol        ISSN： 0300-8584            Impact factor:   3.402


  16 in total

1.  A sensitive and precise plaque assay for herpes virus.

Authors:  W C RUSSELL
Journal:  Nature       Date:  1962-09-08       Impact factor: 49.962

2.  Serological relatedness of herpes simplex viruses. Type-specificity of antibody response.

Authors:  G R Skinner; M E Thouless; S Trueman; J Edwards; A J Gibbs
Journal:  Immunology       Date:  1976-09       Impact factor: 7.397

3.  Comparative analyses of the proteins and antigens of five herpesviruses.

Authors:  R A Killington; J Yeo; R Honess; D H Watson; B E Duncan; I W Halliburton; J Mumford
Journal:  J Gen Virol       Date:  1977-11       Impact factor: 3.891

4.  Augmentation of the neutralisation test for type 1 HSV: evidence of high representation of neutralising antibody in the adult community.

Authors:  P J Holmes; J A Hallworth; D I Stocker; G R Skinner
Journal:  Med Microbiol Immunol       Date:  1985       Impact factor: 3.402

5.  The role of type specific and cross reacting structural antigens in the neutralization of herpes simplex virus types 1 and 2.

Authors:  C Sim; D H Watson
Journal:  J Gen Virol       Date:  1973-05       Impact factor: 3.891

6.  Preparation and immunogenicity of vaccine Ac NFU1 (S-) MRC towards the prevention of herpes genitalis.

Authors:  G R Skinner; C B Woodman; C E Hartley; A Buchan; A Fuller; J Durham; M Synnott; J C Clay; J Melling; C Wiblin; J Wilkins
Journal:  Br J Vener Dis       Date:  1982-12

7.  Immunogenicity and protective efficacy in a rhesus monkey model of vaccine Ac NFUi(S-) MRC against primary type 2 herpes simplex virus infection.

Authors:  G R Skinner; A Buchan; D Williams; J Marsden; C Hartley; G Wilbanks; M Turyk; E S Namkoong
Journal:  Br J Exp Pathol       Date:  1982-08

8.  Detection of type-specific antibody to herpes simplex virus type 1 and 2 in human sera by complement-fixation tests.

Authors:  G R Skinner; C H Hartley; J E Whitney
Journal:  Arch Virol       Date:  1976       Impact factor: 2.574

9.  Role of bovine mammillitis virus towards preparation of an alternative vaccine against herpes simplex virus infections of human subjects.

Authors:  G R Skinner; A Buchan; J Durham; M Cowan; J Davies; K Brookes; G Castrucci
Journal:  Vaccine       Date:  1987-03       Impact factor: 3.641

10.  Immune response to a DNA free herpes simplex vaccine in man.

Authors:  R Cappel; S Sprecher; F Rickaert; F de Cuyper
Journal:  Arch Virol       Date:  1982       Impact factor: 2.574
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  1 in total

1.  Report of twelve years experience in open study of Skinner herpes simplex vaccine towards prevention of herpes genitalis.

Authors:  G R Skinner; C Fink; J Melling; C Wiblin; B Thornton; J Hallworth; W Gardner; P McLeish; C Hartley; A Buchan
Journal:  Med Microbiol Immunol       Date:  1992       Impact factor: 3.402
  1 in total

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