Vicente Molina1, Alba Lubeiro2, Oscar Soto2, Margarita Rodriguez3, Aldara Álvarez4, Rebeca Hernández4, Rodrigo de Luis-García5. 1. Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005 Valladolid, Spain; Psychiatry Service, Clinical Hospital of Valladolid, Ramón y Cajal, 3, 47003 Valladolid, Spain; Neurosciences Institute of Castilla y León (INCYL), Pintor Fernando Gallego, 1, 37007, University of Salamanca, Spain; CIBERSAM (Biomedical Research Network in Mental Health), Instituto de Salud Carlos III, Spain. Electronic address: viente.molina@uva.es. 2. Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005 Valladolid, Spain. 3. Radiology Service, Clinical Hospital of Valladolid, Ramón y Cajal, 3, 47003 Valladolid, Spain. 4. Psychiatry Service, Clinical Hospital of Valladolid, Ramón y Cajal, 3, 47003 Valladolid, Spain. 5. Imaging Processing Laboratory, University of Valladolid, Paseo de Belén, 15, 47011 Valladolid, Spain.
Abstract
BACKGROUND: Spatial and biological characteristics of structural frontal disconnectivity in schizophrenia remain incompletely understood. Simultaneous streamline count (SC) and fractional anisotropy (FA) analyses may yield relevant complementary information to this end. METHODS: Using 3T diffusion magnetic resonance imaging both SC and FA were calculated for the tracts linking lateral and medial subregions of prefrontal cortex (PFC) to cingulate, hippocampus, caudate and thalamus in 27 schizophrenia patients (14 first-episodes) and 27 controls. Relationships of these parameters with cognition, symptoms, treatment doses and illness duration were assessed where significant between-groups differences were detected. RESULTS: Patients showed lower SC and FA in the tracts linking lateral and medial PFC to thalamus (likely corresponding to anterior thalamic peduncle) and lower FA in those linking PFC to caudate (likely through internal capsule), right caudal anterior cingulate and left hippocampus (likely corresponding to hippocampal-prefrontal pathway). Moreover, patients showed greater SC values for the tracts linking medial PFC and left caudal anterior cingulate. SC and FA values for the tracts linking PFC and caudal anterior cingulate were positively related to motor speed, executive function, problem solving and completed categories in WCST. FA for the tract linking right lateral PFC and caudate was directly related to positive symptoms and FA for the tract linking left medial PFC and left thalamus was inversely related to negative symptoms. Treatment doses were not associated with SC or FA values in any tract. Illness duration was negatively associated with SC and FA in the tracts linking PFC and subcortical areas. CONCLUSIONS: Widespread alterations in frontal structural connectivity of PFC can be found in schizophrenia, and are related to cognition, symptoms and illness duration.
BACKGROUND: Spatial and biological characteristics of structural frontal disconnectivity in schizophrenia remain incompletely understood. Simultaneous streamline count (SC) and fractional anisotropy (FA) analyses may yield relevant complementary information to this end. METHODS: Using 3T diffusion magnetic resonance imaging both SC and FA were calculated for the tracts linking lateral and medial subregions of prefrontal cortex (PFC) to cingulate, hippocampus, caudate and thalamus in 27 schizophreniapatients (14 first-episodes) and 27 controls. Relationships of these parameters with cognition, symptoms, treatment doses and illness duration were assessed where significant between-groups differences were detected. RESULTS:Patients showed lower SC and FA in the tracts linking lateral and medial PFC to thalamus (likely corresponding to anterior thalamic peduncle) and lower FA in those linking PFC to caudate (likely through internal capsule), right caudal anterior cingulate and left hippocampus (likely corresponding to hippocampal-prefrontal pathway). Moreover, patients showed greater SC values for the tracts linking medial PFC and left caudal anterior cingulate. SC and FA values for the tracts linking PFC and caudal anterior cingulate were positively related to motor speed, executive function, problem solving and completed categories in WCST. FA for the tract linking right lateral PFC and caudate was directly related to positive symptoms and FA for the tract linking left medial PFC and left thalamus was inversely related to negative symptoms. Treatment doses were not associated with SC or FA values in any tract. Illness duration was negatively associated with SC and FA in the tracts linking PFC and subcortical areas. CONCLUSIONS: Widespread alterations in frontal structural connectivity of PFC can be found in schizophrenia, and are related to cognition, symptoms and illness duration.
Authors: Johanna Seitz-Holland; Joanne D Wojcik; Suheyla Cetin-Karayumak; Amanda E Lyall; Ofer Pasternak; Yogesh Rathi; Mark Vangel; Godfrey Pearlson; Carol Tamminga; John A Sweeney; Brett A Clementz; David A Schretlen; Petra Verena Viher; Katharina Stegmayer; Sebastian Walther; Jungsun Lee; Tim Crow; Anthony James; Aristotle Voineskos; Robert W Buchanan; Philip R Szeszko; Anil K Malhotra; Sinead Kelly; Martha E Shenton; Matcheri S Keshavan; Raquelle I Mesholam-Gately; Marek Kubicki Journal: Mol Psychiatry Date: 2022-08-18 Impact factor: 13.437
Authors: Javier Gomez-Pilar; Rodrigo de Luis-García; Alba Lubeiro; Henar de la Red; Jesús Poza; Pablo Núñez; Roberto Hornero; Vicente Molina Journal: Hum Brain Mapp Date: 2018-04-02 Impact factor: 5.038
Authors: Johanna Seitz-Holland; Suheyla Cetin-Karayumak; Matcheri Keshavan; Marek Kubicki; Joanne D Wojcik; Amanda Lyall; James Levitt; Martha E Shenton; Ofer Pasternak; Carl-Fredrik Westin; Madhura Baxi; Sinead Kelly; Raquelle Mesholam-Gately; Mark Vangel; Godfrey Pearlson; Carol A Tamminga; John A Sweeney; Brett A Clementz; David Schretlen; Petra Verena Viher; Katharina Stegmayer; Sebastian Walther; Jungsun Lee; Tim Crow; Anthony James; Aristotle Voineskos; Robert W Buchanan; Philip R Szeszko; Anil K Malhotra; Yogesh Rathi Journal: Mol Psychiatry Date: 2021-01-22 Impact factor: 13.437
Authors: Javier Gomez-Pilar; Rodrigo de Luis-García; Alba Lubeiro; Nieves de Uribe; Jesús Poza; Pablo Núñez; Marta Ayuso; Roberto Hornero; Vicente Molina Journal: Neuroimage Clin Date: 2018-02-06 Impact factor: 4.881
Authors: João V Nani; Richard S Lee; Camila M Yonamine; Osvaldo A Sant'Anna; Maria A Juliano; Ary Gadelha; Jair J Mari; Mirian A F Hayashi Journal: Sci Rep Date: 2020-10-28 Impact factor: 4.379