Massimo Del Fabbro1, Cristina Bucchi2, Alessandra Lolato3, Stefano Corbella4, Tiziano Testori4, Silvio Taschieri5. 1. Associate Professor, Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Milan; Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. 2. Assistant Professor, Research Centre in Dental Sciences (CICO), Facultad de Odontología, Universidad de La Frontera, Temuco, Chile; PhD Candidate, Departamento de Patología i Terapeútica Experimental, Universitat de Barcelona, Barcelona, Spain. Electronic address: cristina.bucchi@ufrontera.cl. 3. PhD Candidate, Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Milan; Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. 4. Visiting Professor, Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Milan; Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. 5. Academic Researcher, Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Milan; Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Abstract
PURPOSE: The true benefit of autologous platelet concentrates (APCs) for enhancing the healing of postextraction sites is still a matter of debate, and in recent years several clinical trials have addressed this issue. The purpose of this study was to determine the effectiveness of an APC adjunct in the preservation of fresh extraction sockets. MATERIALS AND METHODS: An electronic search was performed on Medline, Embase, Scopus, and the Cochrane Central Register of Controlled Trials. Only controlled clinical trials or randomized clinical trials were included. Selected articles underwent risk-of-bias assessment. The outcomes were complications and adverse events, discomfort and quality of life, bone healing and remodeling assessed by histologic and radiographic techniques, and soft tissue healing. RESULTS: Thirty-three comparative studies were included. Nine articles had a parallel design and 24 had a split-mouth design. Twenty studies were considered to have a low risk of bias and 13 were considered to have a high risk. Overall, 1,193 teeth were extracted from 911 patients. Meta-analysis showed that soft tissue healing, probing depth at 3 months, and bone density at 1, 3, and 6 months were statistically better for the APC group. Qualitative analysis suggested that APCs might be associated with a decrease in swelling and trismus. However, no relevant difference among groups was found for probing depth at 1 month, incidence of alveolar osteitis, acute inflammation or infection, percentage of new bone, and indirect measurement of bone metabolism. CONCLUSION: APCs should be used in postextraction sites to improve clinical and radiographic outcomes such as bone density and soft tissue healing and postoperative symptoms. The actual benefit of APCs on decreasing pain in extraction sockets is still not quantifiable.
PURPOSE: The true benefit of autologous platelet concentrates (APCs) for enhancing the healing of postextraction sites is still a matter of debate, and in recent years several clinical trials have addressed this issue. The purpose of this study was to determine the effectiveness of an APC adjunct in the preservation of fresh extraction sockets. MATERIALS AND METHODS: An electronic search was performed on Medline, Embase, Scopus, and the Cochrane Central Register of Controlled Trials. Only controlled clinical trials or randomized clinical trials were included. Selected articles underwent risk-of-bias assessment. The outcomes were complications and adverse events, discomfort and quality of life, bone healing and remodeling assessed by histologic and radiographic techniques, and soft tissue healing. RESULTS: Thirty-three comparative studies were included. Nine articles had a parallel design and 24 had a split-mouth design. Twenty studies were considered to have a low risk of bias and 13 were considered to have a high risk. Overall, 1,193 teeth were extracted from 911 patients. Meta-analysis showed that soft tissue healing, probing depth at 3 months, and bone density at 1, 3, and 6 months were statistically better for the APC group. Qualitative analysis suggested that APCs might be associated with a decrease in swelling and trismus. However, no relevant difference among groups was found for probing depth at 1 month, incidence of alveolar osteitis, acute inflammation or infection, percentage of new bone, and indirect measurement of bone metabolism. CONCLUSION: APCs should be used in postextraction sites to improve clinical and radiographic outcomes such as bone density and soft tissue healing and postoperative symptoms. The actual benefit of APCs on decreasing pain in extraction sockets is still not quantifiable.
Authors: Marco Annunziata; Luigi Guida; Livia Nastri; Angelantonio Piccirillo; Linda Sommese; Claudio Napoli Journal: Transfus Med Hemother Date: 2018-05-03 Impact factor: 3.747
Authors: Momen A Atieh; Nabeel Hm Alsabeeha; Alan Gt Payne; Sara Ali; Clovis M Jr Faggion; Marco Esposito Journal: Cochrane Database Syst Rev Date: 2021-04-26
Authors: Rodolfo Mauceri; Vera Panzarella; Laura Maniscalco; Alberto Bedogni; Maria Ester Licata; Antonino Albanese; Francesca Toia; Enzo Maria Giuseppe Cumbo; Giuseppina Mazzola; Olga Di Fede; Giuseppina Campisi Journal: Biomed Res Int Date: 2018-08-19 Impact factor: 3.411
Authors: Min He; Xuewen Guo; Tao Li; Xiaoyan Jiang; Yan Chen; Yi Yuan; Bing Chen; Gangyi Yang; Yahan Fan; Ziwen Liang; David G Armstrong; Wuquan Deng Journal: Cell Transplant Date: 2020 Jan-Dec Impact factor: 4.064