| Literature DB >> 28288318 |
Uzma Salar1, Khalid Mohammed Khan2, Jamshed Iqbal3, Syeda Abida Ejaz4, Abdul Hameed1, Mariya Al-Rashida5, Shahnaz Perveen6, Muhammad Nawaz Tahir7.
Abstract
A library of coumarin derived sulfonyl esters (1-38) was synthesized by reacting various hydroxy coumarins with different alkyl and aryl sulfonyl chlorides. All compounds were evaluated for their potential to inhibit alkaline phosphatases (hTNAP and hIAP). Most of the compounds were found to be inhibitors of APs. Compound 20 was found to be the most active hIAP inhibitor (IC50 = 1.11 ± 0.15 μM), whereas, compound 13 was found to be the most active hTNAP inhibitor (IC50 = 0.58 ± 0.17 μM). Detailed structure activity relationship studies (SAR), and molecular docking studies were carried out to identify structural elements necessary for AP inhibition, in addition to rationalize most probable binding site interaction of the inhibitors with the AP enzymes.Entities:
Keywords: Alkaline phosphatase; Coumarins; Docking studies; Inhibitory activity; SAR; Sulfonates
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Year: 2017 PMID： 28288318 DOI： 10.1016/j.ejmech.2017.03.003
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514