Marcela Zúñiga1, Armando Galindo1, María Isabel Galaz2, Maritza Vivanco1, Patricio Romero3, Paulina Balboa1, Claudia Torrejón1. 1. Departamentos de Pediatría y Cirugía Norte, Hospital Roberto del Río, Universidad de Chile, Santiago, Chile. 2. Unidad de Enfermedades Infecciosas Pediátricas, Hospital Roberto del Río, Santiago, Chile. 3. Unidad de Endocrinología Pediátrica, Hospital Roberto del Río, Universidad de Chile, Santiago, Chile.
Abstract
Tenofovir (TDF) is an inhibitor of reverse transcriptase nucleotide analogue, although it has good tolerability and high anti-retroviral activity, its effect on the kidney has been a concern. OBJECTIVE: To describe a girl infected with HIV who presented Fanconi syndrome during antiretroviral therapy with TDF. CLINICAL CASE: We describe a HIV-1-infected girl, who after 18 months treatment with TDF presented loss of strength and pain of the lower extremities with functional impairment. Laboratory findings were consistent with Fanconi syndrome. Radiographs showed bilateral hip fracture and wrists. Full recovery of Fanconi syndrome was achieved four months after changing antiretroviral therapy. CONCLUSIONS: TDF-prescribing physicians must be prepared to detect signs and symptoms of renal dysfunction and immediately consider switching to another antiviral drug.
Tenofovir (TDF) is an inhibitor of reverse transcriptase nucleotide analogue, although it has good tolerability and high anti-retroviral activity, its effect on the kidney has been a concern. OBJECTIVE: To describe a girl infected with HIV who presented Fanconi syndrome during antiretroviral therapy with TDF. CLINICAL CASE: We describe a HIV-1-infected girl, who after 18 months treatment with TDF presented loss of strength and pain of the lower extremities with functional impairment. Laboratory findings were consistent with Fanconi syndrome. Radiographs showed bilateral hip fracture and wrists. Full recovery of Fanconi syndrome was achieved four months after changing antiretroviral therapy. CONCLUSIONS:TDF-prescribing physicians must be prepared to detect signs and symptoms of renal dysfunction and immediately consider switching to another antiviral drug.
Authors: Kedar Joshi; David Boettiger; Stephen Kerr; Takeshi Nishijima; Kinh Van Nguyen; Penh Sun Ly; Man Po Lee; Nagalingeswaran Kumarasamy; Wingwai Wong; Pacharee Kantipong; Do Duy Cuong; Adeeba Kamarulzaman; Jun Yong Choi; Fujie Zhang; Romanee Chaiwarith; Oon Tek Ng; Sasisopin Kiertiburanakul; Benedict Lim Heng Sim; Tuti Parwati Merati; Evy Yunihastuti; Rossana Ditangco; Jeremy Ross; Sanjay Pujari Journal: Pharmacoepidemiol Drug Saf Date: 2018-09-24 Impact factor: 2.890