| Literature DB >> 2828792 |
D A Bennett1, P S Bernard, C L Amrick.
Abstract
The PCP-like compounds ketamine and dexoxadrol were evaluated in two behavioral test procedures known to be sensitive to competitive N-methyl-D-aspartate (NMDA) receptor antagonists. In the NMDA-induced convulsion test in mice, ketamine and dexoxadrol blocked convulsant activity only at doses that also induced nonspecific effects of PCP-like behaviors, thereby confounding the interpretation of results. These compounds also blocked NMDA-induced discriminative stimuli in rats; however, this effect was produced at doses lower than those which induced the nonspecific behavioral effects. These results provide evidence that in behavioral procedures, PCP-like compounds may block excitatory amino acid receptor stimulation by NMDA. The NMDA discrimination identifies these interactions without the influence of motor deficit or other behavioral motor effects.Entities:
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Year: 1988 PMID： 2828792 DOI： 10.1016/0024-3205(88)90083-5
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037