Oktay Bulur1, Kursat Dal1, Derun Taner Ertugrul2, Murat Eser1, Fatma Kaplan Efe1, Serdar Karakaya1, Kubilay Şahin3, Salih Baser1, Naim Ata1, Aysun Aybal Kutlugun4, Esin Beyan1. 1. a Department of Internal Medicine , Kecioren Teaching and Research Hospital , Kecioren , Ankara , Turkey. 2. b Department of Endocrinology and Metabolism , Kecioren Teaching and Research Hospital , Kecioren , Ankara , Turkey. 3. c Department of Rheumatology , Kecioren Teaching and Research Hospital , Kecioren , Ankara , Turkey. 4. d Department of Nephrology , Kecioren Teaching and Research , Kecioren , Ankara , Turkey ; Hospital.
Abstract
BACKGROUND: It has been known that thyroid hormones may affect renal function. In this study, we aimed to investigate the effect of levothyroxine replacement on renal function in hypothyroid patients before and after treatment. METHODS: We retrospectively investigated free T3 (fT3), free T4 (fT4), TSH, creatinine, and eGFR measurements during both hypothyroid and euthyroid states of hypothyroid patients. The eGFR was calculated using the simplified Modification of Diet in Renal Disease formula. RESULTS: fT3, fT4, and eGFR measurements increased, meanwhile creatinine and TSH levels decreased significantly after euthyroidism was achieved with levothyroxine treatment (p < 0.0001 for all). The correlation analyses revealed that ∆creatinine and ∆TSH levels were significantly correlated before and after levothyroxine treatment (r: 0.288, p < 0.0001). ∆eGFR and ∆TSH levels were significantly correlated before and after LT4 treatment (r: -0.272, p < 0.0001). CONCLUSION: In this study, we evaluated creatinine and eGFR levels in patients with hypothyroidism and found out that renal function improved in most patients after euthyroidism was achieved. In some patients, above-normal creatinine levels completely returned to normal once the patients became euthyroid.
BACKGROUND: It has been known that thyroid hormones may affect renal function. In this study, we aimed to investigate the effect of levothyroxine replacement on renal function in hypothyroidpatients before and after treatment. METHODS: We retrospectively investigated free T3 (fT3), free T4 (fT4), TSH, creatinine, and eGFR measurements during both hypothyroid and euthyroid states of hypothyroidpatients. The eGFR was calculated using the simplified Modification of Diet in Renal Disease formula. RESULTS: fT3, fT4, and eGFR measurements increased, meanwhile creatinine and TSH levels decreased significantly after euthyroidism was achieved with levothyroxine treatment (p < 0.0001 for all). The correlation analyses revealed that ∆creatinine and ∆TSH levels were significantly correlated before and after levothyroxine treatment (r: 0.288, p < 0.0001). ∆eGFR and ∆TSH levels were significantly correlated before and after LT4 treatment (r: -0.272, p < 0.0001). CONCLUSION: In this study, we evaluated creatinine and eGFR levels in patients with hypothyroidism and found out that renal function improved in most patients after euthyroidism was achieved. In some patients, above-normal creatinine levels completely returned to normal once the patients became euthyroid.
Authors: Benjamin Schairer; Viktoria Jungreithmayr; Mario Schuster; Thomas Reiter; Harald Herkner; Alois Gessl; Gürkan Sengölge; Wolfgang Winnicki Journal: Sci Rep Date: 2020-02-07 Impact factor: 4.379