Dror Marchaim1,2, Dana Levit2, Roy Zigron2, Michal Gordon3, Tsillia Lazarovitch4, Joao A Carrico5, Vered Chalifa-Caspi3, Jacob Moran-Gilad6,7,8. 1. Unit of Infectious Diseases, Assaf Harofeh Medical Center, Zerifin, Israel. 2. Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. 3. NIBN, Ben-Gurion University of the Negev, Beer-Sheva, Israel. 4. Clinical Microbiology Laboratory, Assaf Harofeh Medical Center, Zerifin, Israel. 5. Instituto de Microbiologia & Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal. 6. Public Health Services, Ministry of Health, Jerusalem, Israel. 7. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. 8. ESCMID Study Group for Genomic & Molecular Diagnostics (ESGMD), Basel, Switzerland.
Abstract
AIM: The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata. METHODS & RESULTS: Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly analyzed at a single center, at least one transmission opportunity was evident for 85% of patients. This implies that patient-to-patient transmission is the major mode of A. baumannii acquisitions in health facilities. Moreover, all patients who died immediately (<24 h of admission) were infected with a single clone (ST457; relative risk = 1.6; p = 0.05). CONCLUSION: This preliminary analysis should prompt further investigation by mapping genomic virulence determinants among A. baumannii ST457 lineage compared with other strains.
AIM: The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata. METHODS & RESULTS: Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly analyzed at a single center, at least one transmission opportunity was evident for 85% of patients. This implies that patient-to-patient transmission is the major mode of A. baumannii acquisitions in health facilities. Moreover, all patients who died immediately (<24 h of admission) were infected with a single clone (ST457; relative risk = 1.6; p = 0.05). CONCLUSION: This preliminary analysis should prompt further investigation by mapping genomic virulence determinants among A. baumannii ST457 lineage compared with other strains.
Authors: M Nazmul Huda; Shaikh M Ahmad; Karen M Kalanetra; Diana H Taft; Md J Alam; Afsana Khanam; Rubhana Raqib; Mark A Underwood; David A Mills; Charles B Stephensen Journal: J Nutr Date: 2019-06-01 Impact factor: 4.798