Literature DB >> 28287239

Structural insights into the EthR-DNA interaction using native mass spectrometry.

Daniel Shiu-Hin Chan1, Wei-Guang Seetoh1, Brendan N McConnell1, Dijana Matak-Vinković1, Sherine E Thomas2, Vitor Mendes2, Michal Blaszczyk2, Anthony G Coyne1, Tom L Blundell2, Chris Abell1.   

Abstract

EthR is a transcriptional repressor that increases Mycobacterium tuberculosis resistance to ethionamide. In this study, the EthR-DNA interaction has been investigated by native electrospray-ionization mass spectrometry for the first time. The results show that up to six subunits of EthR are able to bind to its operator.

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Year:  2017        PMID： 28287239      PMCID： PMC5868724          DOI： 10.1039/c7cc00804j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  18 in total

1.  ATP- and ADP-dnaA protein, a molecular switch in gene regulation.

Authors:  C Speck; C Weigel; W Messer
Journal:  EMBO J       Date:  1999-11-01       Impact factor: 11.598

2.  Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR.

Authors:  Maria A Schumacher; Marshall C Miller; Steve Grkovic; Melissa H Brown; Ronald A Skurray; Richard G Brennan
Journal:  EMBO J       Date:  2002-03-01       Impact factor: 11.598

3.  Advantages and drawbacks of nanospray for studying noncovalent protein-DNA complexes by mass spectrometry.

Authors:  Valérie Gabelica; Christelle Vreuls; Patrice Filée; Valérie Duval; Bernard Joris; Edwin De Pauw
Journal:  Rapid Commun Mass Spectrom       Date:  2002       Impact factor: 2.419

Review 4.  The TetR family of transcriptional repressors.

Authors:  Juan L Ramos; Manuel Martínez-Bueno; Antonio J Molina-Henares; Wilson Terán; Kazuya Watanabe; Xiaodong Zhang; María Trinidad Gallegos; Richard Brennan; Raquel Tobes
Journal:  Microbiol Mol Biol Rev       Date:  2005-06       Impact factor: 11.056

5.  Determination of refractive index increment ratios for protein-nucleic acid complexes by surface plasmon resonance.

Authors:  Carmelo Di Primo; Isabelle Lebars
Journal:  Anal Biochem       Date:  2007-06-15       Impact factor: 3.365

6.  Enthalpic factors override the polyelectrolyte effect in the binding of EGR1 transcription factor to DNA.

Authors:  David C Mikles; Vikas Bhat; Brett J Schuchardt; Caleb B McDonald; Amjad Farooq
Journal:  J Mol Recognit       Date:  2014-02       Impact factor: 2.137

7.  EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator.

Authors:  Jean Engohang-Ndong; David Baillat; Marc Aumercier; Flore Bellefontaine; Gurdyal S Besra; Camille Locht; Alain R Baulard
Journal:  Mol Microbiol       Date:  2004-01       Impact factor: 3.501

8.  Synthetic EthR inhibitors boost antituberculous activity of ethionamide.

Authors:  Nicolas Willand; Bertrand Dirié; Xavier Carette; Pablo Bifani; Amit Singhal; Matthieu Desroses; Florence Leroux; Eve Willery; Vanessa Mathys; Rebecca Déprez-Poulain; Guy Delcroix; Frédéric Frénois; Marc Aumercier; Camille Locht; Vincent Villeret; Benoit Déprez; Alain R Baulard
Journal:  Nat Med       Date:  2009-05-03       Impact factor: 53.440

Review 9.  Crucial components of Mycobacterium type II fatty acid biosynthesis (Fas-II) and their inhibitors.

Authors:  Xiangke Duan; Xiaohong Xiang; Jianping Xie
Journal:  FEMS Microbiol Lett       Date:  2014-10-21       Impact factor: 2.742

Review 10.  Two decades of studying non-covalent biomolecular assemblies by means of electrospray ionization mass spectrometry.

Authors:  Gillian R Hilton; Justin L P Benesch
Journal:  J R Soc Interface       Date:  2012-02-07       Impact factor: 4.118
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  4 in total

1.  Characterization of a Salmonella Transcription Factor-DNA Complex and Identification of the Inducer by Native Mass Spectrometry.

Authors:  Blake E Szkoda; Angela Di Capua; Joy Shaffer; Edward J Behrman; Vicki H Wysocki; Venkat Gopalan
Journal:  J Mol Biol       Date:  2022-02-14       Impact factor: 5.469

2.  A DNA-Binding Protein Tunes Septum Placement during Bacillus subtilis Sporulation.

Authors:  Emily E Brown; Allyssa K Miller; Inna V Krieger; Ryan M Otto; James C Sacchettini; Jennifer K Herman
Journal:  J Bacteriol       Date:  2019-07-24       Impact factor: 3.490

Review 3.  Advances in MS Based Strategies for Probing Ligand-Target Interactions: Focus on Soft Ionization Mass Spectrometric Techniques.

Authors:  Guilin Chen; Minxia Fan; Ye Liu; Baoqing Sun; Meixian Liu; Jianlin Wu; Na Li; Mingquan Guo
Journal:  Front Chem       Date:  2019-10-23       Impact factor: 5.221

4.  The complex formed between a synthetic RNA aptamer and the transcription repressor TetR is a structural and functional twin of the operator DNA-TetR regulator complex.

Authors:  Florian C Grau; Jeannine Jaeger; Florian Groher; Beatrix Suess; Yves A Muller
Journal:  Nucleic Acids Res       Date:  2020-04-06       Impact factor: 16.971
  4 in total

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