Gold catalysis: synthesis of spiro, bridged, and fused ketal natural products.

In the last decade the use of homogenous gold catalysts has rapidly grown and become a valuable tool for complex natural product synthesis. Spiroketal natural products are valuable targets for total synthesis and medicinal chemistry applications. The use of gold catalysts has emerged as a useful tool to synthesise these privileged scaffolds. This review summarises the application of gold catalysis for the syntheses of spiro, bridged and fused ketal natural products.