Literature DB >> 28286899

Epigenetics of kidney disease.

Nicola Wanner1,2,3, Wibke Bechtel-Walz4,5.   

Abstract

DNA methylation and histone modifications determine renal programming and the development and progression of renal disease. The identification of the way in which the renal cell epigenome is altered by environmental modifiers driving the onset and progression of renal diseases has extended our understanding of the pathophysiology of kidney disease progression. In this review, we focus on current knowledge concerning the implications of epigenetic modifications during renal disease from early development to chronic kidney disease progression including renal fibrosis, diabetic nephropathy and the translational potential of identifying new biomarkers and treatments for the prevention and therapy of chronic kidney disease and end-stage kidney disease.

Entities:  

Keywords:  Chronic kidney disease; Diabetes; Epigenetic therapy; Epigenetics; Kidney

Mesh：

Year:  2017        PMID： 28286899     DOI： 10.1007/s00441-017-2588-x

Source DB:  PubMed          Journal:  Cell Tissue Res        ISSN： 0302-766X            Impact factor:   5.249


  23 in total

Review 1.  Epigenetics and epigenomics in diabetic kidney disease and metabolic memory.

Authors:  Mitsuo Kato; Rama Natarajan
Journal:  Nat Rev Nephrol       Date:  2019-06       Impact factor: 28.314

Review 2.  Epigenetic Risk Profile of Diabetic Kidney Disease in High-Risk Populations.

Authors:  Lixia Xu; Rama Natarajan; Zhen Chen
Journal:  Curr Diab Rep       Date:  2019-02-07       Impact factor: 4.810

Review 3.  Cellular Senescence and Regulated Cell Death of Tubular Epithelial Cells in Diabetic Kidney Disease.

Authors:  Shuang Shen; Chuanyuan Ji; Kaifeng Wei
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-28       Impact factor: 6.055

4.  Targeting histone methyltransferase enhancer of zeste homolog-2 inhibits renal epithelial-mesenchymal transition and attenuates renal fibrosis.

Authors:  Xiaoxu Zhou; Chongxiang Xiong; Evelyn Tolbert; Ting C Zhao; George Bayliss; Shougang Zhuang
Journal:  FASEB J       Date:  2018-05-18       Impact factor: 5.191

Review 5.  Epigenetic modifications of Klotho expression in kidney diseases.

Authors:  Jinkun Xia; Wangsen Cao
Journal:  J Mol Med (Berl)       Date:  2021-02-06       Impact factor: 4.599

6.  Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia.

Authors:  Fenglin Wang; Jenny Ngo; Yuwen Li; Hongbing Liu; Chao-Hui Chen; Zubaida Saifudeen; Maria Luisa S Sequeira-Lopez; Samir S El-Dahr
Journal:  Epigenetics       Date:  2020-12-29       Impact factor: 4.528

Review 7.  Histone deacetylase 3 (HDAC3) as an important epigenetic regulator of kidney diseases.

Authors:  Lijun Zhang; Wangsen Cao
Journal:  J Mol Med (Berl)       Date:  2021-10-26       Impact factor: 4.599

8.  Blocking the histone lysine 79 methyltransferase DOT1L alleviates renal fibrosis through inhibition of renal fibroblast activation and epithelial-mesenchymal transition.

Authors:  Lirong Liu; Jianan Zou; Yingjie Guan; Yunhe Zhang; Wei Zhang; Xiaoxu Zhou; Chongxiang Xiong; Evelyn Tolbert; Ting C Zhao; George Bayliss; Shougang Zhuang
Journal:  FASEB J       Date:  2019-08-02       Impact factor: 5.191

Review 9.  Policy in pediatric nephrology: successes, failures, and the impact on disparities.

Authors:  Jill R Krissberg; Scott M Sutherland; Lisa J Chamberlain; Paul H Wise
Journal:  Pediatr Nephrol       Date:  2020-09-23       Impact factor: 3.714

10.  Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis.

Authors:  Lirong Liu; Feng Liu; Yingjie Guan; Jianan Zou; Chunyun Zhang; Chongxiang Xiong; Ting C Zhao; George Bayliss; Xiaogang Li; Shougang Zhuang
Journal:  FASEB J       Date:  2021-07       Impact factor: 5.834
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