Literature DB >> 2828659

The two proteins encoded by the cottontail rabbit papillomavirus E6 open reading frame differ with respect to localization and phosphorylation.

M S Barbosa1, F O Wettstein.   

Abstract

Cottontail rabbit papillomavirus-induced tumors contain two E6-coding transcripts. A major transcript can code for a short E6 protein initiated at AUG codon 2, and a minor one could code for a long E6 initiated at AUG 1. We have identified the two proteins expressed in COS-7 cells (M. Barbosa and F. O. Wettstein, J. Virol. 61:2938-2942, 1987). The properties of the two proteins are distinctly different. The long E6 is predominantly present in the nucleus, in which it appears to be associated with the nuclear matrix. Minor portions of the long E6 are located in equal amounts in both the soluble cytoplasmic and the membrane fractions. The short E6 is a soluble cytoplasmic protein phosphorylated at serine residues.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2828659      PMCID： PMC253674          DOI： 10.1128/JVI.62.3.1088-1092.1988

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  33 in total

1.  12-O-tetradecanoylphorbol-13-acetate stimulates phosphorylation of the 58,000-Mr form of polyomavirus middle T antigen in vivo: implications for a possible role of protein kinase C in middle T function.

Authors:  J T Matthews; T L Benjamin
Journal:  J Virol       Date:  1986-05       Impact factor: 5.103

2.  Fine structure of the cottontail rabbit papillomavirus mRNAs expressed in the transplantable VX2 carcinoma.

Authors:  O Danos; E Georges; G Orth; M Yaniv
Journal:  J Virol       Date:  1985-03       Impact factor: 5.103

3.  Induction of nuclear transport with a synthetic peptide homologous to the SV40 T antigen transport signal.

Authors:  R E Lanford; P Kanda; R C Kennedy
Journal:  Cell       Date:  1986-08-15       Impact factor: 41.582

4.  Purification and properties of an endo-alpha-N-acetyl-D-galactosaminidase from Diplococcus pneumoniae.

Authors:  J Umemoto; V P Bhavanandan; E A Davidson
Journal:  J Biol Chem       Date:  1977-12-10       Impact factor: 5.157

5.  The specific site of tunicamycin inhibition in the formation of dolichol-bound N-acetylglucosamine derivatives.

Authors:  L Lehle; W Tanner
Journal:  FEBS Lett       Date:  1976-11-15       Impact factor: 4.124

6.  Association of simian virus 40 T antigen with the nuclear matrix of infected and transformed monkey cells.

Authors:  L Covey; Y Choi; C Prives
Journal:  Mol Cell Biol       Date:  1984-07       Impact factor: 4.272

7.  Biology and biochemistry of papillomaviruses.

Authors:  H Pfister
Journal:  Rev Physiol Biochem Pharmacol       Date:  1984       Impact factor: 5.545

8.  A simple method for displaying the hydropathic character of a protein.

Authors:  J Kyte; R F Doolittle
Journal:  J Mol Biol       Date:  1982-05-05       Impact factor: 5.469

9.  The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein.

Authors:  D Smotkin; F O Wettstein
Journal:  J Virol       Date:  1987-05       Impact factor: 5.103

10.  V-myc- and c-myc-encoded proteins are associated with the nuclear matrix.

Authors:  R N Eisenman; C Y Tachibana; H D Abrams; S R Hann
Journal:  Mol Cell Biol       Date:  1985-01       Impact factor: 4.272
View more
  9 in total

1.  Synonymous codon changes in the oncogenes of the cottontail rabbit papillomavirus lead to increased oncogenicity and immunogenicity of the virus.

Authors:  Nancy M Cladel; Lynn R Budgeon; Jiafen Hu; Karla K Balogh; Neil D Christensen
Journal:  Virology       Date:  2013-02-20       Impact factor: 3.616

2.  E2 of cottontail rabbit papillomavirus is a nuclear phosphoprotein translated from an mRNA encoding multiple open reading frames.

Authors:  M S Barbosa; F O Wettstein
Journal:  J Virol       Date:  1988-09       Impact factor: 5.103

3.  Amino acid residues in the carboxy-terminal region of cottontail rabbit papillomavirus E6 influence spontaneous regression of cutaneous papillomas.

Authors:  Jiafen Hu; Nancy M Cladel; Martin D Pickel; Neil D Christensen
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

4.  Intracellular localization and DNA-binding properties of human papillomavirus type 18 E6 protein expressed with a baculovirus vector.

Authors:  S R Grossman; R Mora; L A Laimins
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

5.  Transforming properties of the cottontail rabbit papillomavirus oncoproteins Le6 and SE6 and of the E8 protein.

Authors:  J B Harry; F O Wettstein
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

6.  Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1.

Authors:  A Schmitt; J B Harry; B Rapp; F O Wettstein; T Iftner
Journal:  J Virol       Date:  1994-11       Impact factor: 5.103

7.  Identification of three transforming proteins encoded by cottontail rabbit papillomavirus.

Authors:  C Meyers; J Harry; Y L Lin; F O Wettstein
Journal:  J Virol       Date:  1992-03       Impact factor: 5.103

Review 8.  A profusion of controls.

Authors:  M Kozak
Journal:  J Cell Biol       Date:  1988-07       Impact factor: 10.539

Review 9.  Pushing the limits of the scanning mechanism for initiation of translation.

Authors:  Marilyn Kozak
Journal:  Gene       Date:  2002-10-16       Impact factor: 3.688
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.