| Literature DB >> 28286267 |
Dandan Xia1, Xiaoming Yang1, Wenxue Liu1, Fangqian Shen1, Jufang Pan1, Yu Lin1, Na Du1, Yunyan Sun1, Xiaowei Xi2.
Abstract
Chromatin Assembly Factor 1, subunit A (CHAF1A) can regulate cell proliferation, DNA repair and epigenetic changes in embryonic stem cells and it has been reported that over-expression of CHAF1A is associated with several human diseases including cancer. However, the expression and function of CHAF1A in Epithelial Ovarian Cancer (EOC) are rarely reported at present. In this study, we found that the positive staining of CHAF1A in EOC was higher than that in normal tissues and over-expression of CHAF1A was strongly associated with cancer stage and lymph node metastasis. Knockdown of CHAF1A by siRNA in EOC inhibited cell proliferation, reduced colony formation, caused G0/G1 phase arrest and promoted cell apoptosis. Taken together, the high expression of CHAF1A promotes cell proliferation and inhibits cell apoptosis and CHAF1A may be developed as a prognosis biomarker and potential therapeutic target of EOC.Entities:
Keywords: Apoptosis; CHAF1A; Cell cycle; Epithelial Ovarian Cancer; Proliferation
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Year: 2017 PMID： 28286267 DOI： 10.1016/j.bbrc.2017.03.026
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575