R Cerneviciute1, S M Sahebally2, K Ahmed1, M Murphy1, W Mahmood1, S R Walsh1. 1. Discipline of Surgery, Lambe Institute, National University of Ireland, Galway, Ireland. 2. Discipline of Surgery, Lambe Institute, National University of Ireland, Galway, Ireland. Electronic address: sahebalm@tcd.ie.
Abstract
BACKGROUND: Arteriovenous fistula (AVF) formation is the most common vascular access procedure for patients requiring haemodialysis. However, it is associated with high failure rates, influenced by vessel diameter and arterial inflow. Mode of anaesthesia may affect these factors, and subsequently AVF maturation rates. OBJECTIVE: To perform a systematic review and meta-analysis to assess the effect of anaesthesia type for autologous primary radiocephalic or brachiocephalic AVF creation on subsequent fistula failure rates. METHODS: The online databases of Medline, EMBASE, CINAHL, The Cochrane Database of Systematic Reviews, ClinicalTrials.gov, and Google Scholar as well as vascular and anaesthesiology conference abstracts were searched on August 1, 2016. Randomised control trials (RCTs) that reported the effect of anaesthesia type on subsequent failure rates during autologous AVF creation were included. Two independent reviewers performed methodological assessment and data extraction. Random effects models were used to calculate pooled effect size estimates. A sensitivity analysis was also carried out. RESULTS: Four RCTs (286 patients) were identified with 286 autologous AVFs. There were 48 fistula failures. Most of the studies suffered from significant methodological flaws. There was a significantly lower failure rate among patients undergoing regional (12/143) compared with local (36/143) anaesthesia (OR 0.28, 95% CI 0.14-0.57). On sensitivity analysis, having excluded the most heavily weighted study, the results remained significant (OR 0.20, 95% CI 0.05-0.75). CONCLUSIONS: The use of regional anaesthesia is associated with lower AVF failure rates when compared with local anaesthesia in patients undergoing primary forearm AVF formation for haemodialysis.
BACKGROUND:Arteriovenous fistula (AVF) formation is the most common vascular access procedure for patients requiring haemodialysis. However, it is associated with high failure rates, influenced by vessel diameter and arterial inflow. Mode of anaesthesia may affect these factors, and subsequently AVF maturation rates. OBJECTIVE: To perform a systematic review and meta-analysis to assess the effect of anaesthesia type for autologous primary radiocephalic or brachiocephalic AVF creation on subsequent fistula failure rates. METHODS: The online databases of Medline, EMBASE, CINAHL, The Cochrane Database of Systematic Reviews, ClinicalTrials.gov, and Google Scholar as well as vascular and anaesthesiology conference abstracts were searched on August 1, 2016. Randomised control trials (RCTs) that reported the effect of anaesthesia type on subsequent failure rates during autologous AVF creation were included. Two independent reviewers performed methodological assessment and data extraction. Random effects models were used to calculate pooled effect size estimates. A sensitivity analysis was also carried out. RESULTS: Four RCTs (286 patients) were identified with 286 autologous AVFs. There were 48 fistula failures. Most of the studies suffered from significant methodological flaws. There was a significantly lower failure rate among patients undergoing regional (12/143) compared with local (36/143) anaesthesia (OR 0.28, 95% CI 0.14-0.57). On sensitivity analysis, having excluded the most heavily weighted study, the results remained significant (OR 0.20, 95% CI 0.05-0.75). CONCLUSIONS: The use of regional anaesthesia is associated with lower AVF failure rates when compared with local anaesthesia in patients undergoing primary forearm AVF formation for haemodialysis.
Authors: Emma Aitken; Rachel Kearns; Lucian Gaianu; Andrew Jackson; Mark Steven; John Kinsella; Marc Clancy; Alan Macfarlane Journal: J Am Soc Nephrol Date: 2020-07-24 Impact factor: 10.121
Authors: Alan Jr Macfarlane; Rachel J Kearns; Marc James Clancy; David Kingsmore; Karen Stevenson; Andrew Jackson; Patrick Mark; Margaret Aitken; Ramani Moonesinghe; Cecilia Vindrola-Padros; Lucian Gaianu; Gavin Pettigrew; Reza Motallebzadeh; Nikolaos Karydis; Alex Vesey; Rita Singh; Thalakunte Muniraju; Stuart Suttie; Alex McConnachie; Kirsty Wetherall; Kariem El-Boghdadly; Rosemary Hogg; Iain Thomson; Vishal Nangalia; Emma Aitken Journal: BMJ Open Date: 2021-12-22 Impact factor: 2.692