Lindsay W Victoria1, Ellen M Whyte2, Meryl A Butters2, Barnett S Meyers3, George S Alexopoulos3, Benoit H Mulsant4, Anthony J Rothschild5, Samprit Banerjee6, Alastair J Flint7. 1. Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine and New York-Presbyterian Hospital, Westchester Division, White Plains, NY. Electronic address: liv3002@med.cornell.edu. 2. Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA. 3. Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine and New York-Presbyterian Hospital, Westchester Division, White Plains, NY. 4. Centre for Addiction and Mental Health, Toronto, Ontario, Canada. 5. University of Massachusetts Medical School and University of Massachusetts Memorial Health Care, Worcester, MA. 6. Department of Healthcare Policy and Research, Weill Cornell Medicine, New York, NY. 7. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University Health Network, Toronto, Ontario, Canada.
Abstract
OBJECTIVE: To characterize cognitive function at baseline and investigate the relationship between change in cognition, depression, and psychosis after treatment among older adults with major depressive disorder with psychotic features. METHODS: This was a secondary analysis of a double-blind, randomized, controlled treatment trial at inpatient and outpatient settings at four academic health centers on "Young Old" (aged 60-71 years, N = 71) and "Older" (aged 72-86 years, N = 71) participants diagnosed with psychotic depression. Olanzapine plus sertraline or olanzapine plus placebo were given until week 12 or termination. RESULTS: At baseline, Young Old and Older participants did not differ on measures of depression severity or global cognition, information processing speed, and executive function. Improvement in depressive and psychotic symptoms from baseline to treatment end was similar in both the Young Old and Older groups. However, improvement in depressive symptoms was significantly associated with improvement in global cognitive function in Young Old participants but not in Older participants. CONCLUSION:Cognitive dysfunction was not a detriment to improvement in symptoms of psychotic major depression in our geriatric patients. Young Old and Older patients improved to a similar degree on measures of depression and delusions from baseline to treatment end. However, improvement in cognition over the course of treatment was more prominent in the Young Old group than in the Older group.
RCT Entities:
OBJECTIVE: To characterize cognitive function at baseline and investigate the relationship between change in cognition, depression, and psychosis after treatment among older adults with major depressive disorder with psychotic features. METHODS: This was a secondary analysis of a double-blind, randomized, controlled treatment trial at inpatient and outpatient settings at four academic health centers on "Young Old" (aged 60-71 years, N = 71) and "Older" (aged 72-86 years, N = 71) participants diagnosed with psychotic depression. Olanzapine plus sertraline or olanzapine plus placebo were given until week 12 or termination. RESULTS: At baseline, Young Old and Older participants did not differ on measures of depression severity or global cognition, information processing speed, and executive function. Improvement in depressive and psychotic symptoms from baseline to treatment end was similar in both the Young Old and Older groups. However, improvement in depressive symptoms was significantly associated with improvement in global cognitive function in Young Old participants but not in Older participants. CONCLUSION:Cognitive dysfunction was not a detriment to improvement in symptoms of psychotic major depression in our geriatric patients. Young Old and Older patients improved to a similar degree on measures of depression and delusions from baseline to treatment end. However, improvement in cognition over the course of treatment was more prominent in the Young Old group than in the Older group.
Authors: Drenna Waldrop; Crista Irwin; W Chance Nicholson; Cheryl A Lee; Allison Webel; Pariya L Fazeli; David E Vance Journal: J Assoc Nurses AIDS Care Date: 2021 May-Jun 01 Impact factor: 1.809
Authors: Shawn M McClintock; Lex Minto; David A Denney; K Chase Bailey; C Munro Cullum; Vonetta M Dotson Journal: Curr Psychiatry Rep Date: 2021-07-13 Impact factor: 8.081