M T Chavez1, J P Sharpe1, T O'Brien2, K T Patton3, D C Portnoy4, N A VanderWalde5, J L Deneve1, D Shibata1, S W Behrman1, P V Dickson6. 1. Department of Surgery, Division of Surgical Oncology, University of Tennessee Health Science Center, Memphis, TN, USA. 2. Memphis Pathology Group, Memphis, TN, USA. 3. Pathology Group of the Midsouth, Germantown, TN, USA. 4. Division of Hematology/Oncology, University of Tennessee Health Science Center and West Cancer Center, Memphis, TN, USA. 5. Department of Radiation Oncology, University of Tennessee Health Science Center and West Cancer Center, Memphis, TN, USA. 6. Department of Surgery, Division of Surgical Oncology, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: pdickso1@uthsc.edu.
Abstract
INTRODUCTION: The purpose of this study was to evaluate outcomes following pancreaticoduodenectomy(PD) for ampullary adenocarcinoma(AAC). METHODS: We evaluated patients having undergone PD for AAC and the impact of clinical/histopathologic factors and adjuvant therapy(AT) on survival. RESULTS: 52 patients underwent potentially curative PD. Perineural and lymphovascular invasion were associated with decreased survival. There was no difference in survival between patients treated with PD vs. PD+AT, however, AT was more often administered to patients with N1 vs. N0 and stage II/III vs. I disease. Among patients receiving AT, we observed a trend towards improved survival when radiation was included. Recurrence occurred in 7/18(39%) stage I patients, only 2(7%) of which received AT. CONCLUSION: AT did not improve survival, however was more commonly administered in advanced disease. Stage I patients had high recurrence rates but rarely received AT. Prospective evaluation of appropriate AT regimens and use in early stage patients should be considered.
INTRODUCTION: The purpose of this study was to evaluate outcomes following pancreaticoduodenectomy(PD) for ampullary adenocarcinoma(AAC). METHODS: We evaluated patients having undergone PD for AAC and the impact of clinical/histopathologic factors and adjuvant therapy(AT) on survival. RESULTS: 52 patients underwent potentially curative PD. Perineural and lymphovascular invasion were associated with decreased survival. There was no difference in survival between patients treated with PD vs. PD+AT, however, AT was more often administered to patients with N1 vs. N0 and stage II/III vs. I disease. Among patients receiving AT, we observed a trend towards improved survival when radiation was included. Recurrence occurred in 7/18(39%) stage I patients, only 2(7%) of which received AT. CONCLUSION: AT did not improve survival, however was more commonly administered in advanced disease. Stage I patients had high recurrence rates but rarely received AT. Prospective evaluation of appropriate AT regimens and use in early stage patients should be considered.
Authors: Brett L Ecker; Charles M Vollmer; Stephen W Behrman; Valentina Allegrini; John Aversa; Chad G Ball; Courtney E Barrows; Adam C Berger; Martha N Cagigas; John D Christein; Elijah Dixon; William E Fisher; Mollie Freedman-Weiss; Francisco Guzman-Pruneda; Robert H Hollis; Michael G House; Tara S Kent; Stacy J Kowalsky; Giuseppe Malleo; Ronald R Salem; Roberto Salvia; Carl R Schmidt; Thomas F Seykora; Richard Zheng; Amer H Zureikat; Paxton V Dickson Journal: JAMA Surg Date: 2019-08-01 Impact factor: 14.766