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Literature DB >> 2828556

Multiple sclerosis and human T-cell lymphotropic retroviruses: negative serological results in 135 German patients.

J Schneider¹, B Kitze, G Hunsmann, I Wendler, L Kappos.

Abstract

A total of 135 sera and 18 cerebrospinal fluid (CSF) samples from patients with multiple sclerosis (MS) were screened for antibodies to human T-cell lymphotropic virus type I (HTLV-I) and human immunodeficiency virus (HIV) by ELISA tests. None of the sera or CSF reacted with HIV antigens. Only 3 out of 135 MS sera but no MS CSF showed increased reactions in the ELISA test for HTLV-I. However, these positive reactions were classified as non-specific by immunoprecipitation. Thus no serological evidence for infection with HIV, HTLV-I, or a related retrovirus was found in the MS patients.

Entities: Disease Species

Mesh：

Substances：
Antibodies, Viral

Year: 1987 PMID： 2828556 DOI： 10.1007/BF00718019

Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849

14 in total

1. Lack of antibody to HTLV-I and HIV in patients with multiple sclerosis from France and French West Indies.

Authors: A Gessain; L Abel; G De-The; J C Vernant; P Raverdy; A Guillard
Journal: Br Med J (Clin Res Ed) Date: 1986-08-16

2. Search for HTLV-I and LAV/HTLV-III antibodies in serum and CSF of multiple sclerosis patients.

Authors: A De Rossi; P Gallo; B Tavolato; L Callegaro; L Chieco-Bianchi
Journal: Acta Neurol Scand Date: 1986-08 Impact factor: 3.209

3. Sera from patients with multiple sclerosis react with human cell T lymphotropic virus-I gag proteins but not env proteins--Western blotting analysis.

Authors: M Ohta; K Ohta; F Mori; H Nishitani; T Saida
Journal: J Immunol Date: 1986-12-01 Impact factor: 5.422

2. A soluble form of tumour necrosis factor receptor in cerebrospinal fluid and serum of HTLV-I-associated myelopathy and other neurological diseases.

Authors: M Puccioni-Sohler; P Rieckmann; B Kitze; P Lange; M Albrecht; K Felgenhauer
Journal: J Neurol Date: 1995-03 Impact factor: 4.849

2 in total

Multiple sclerosis and human T-cell lymphotropic retroviruses: negative serological results in 135 German patients.

1. Lack of antibody to HTLV-I and HIV in patients with multiple sclerosis from France and French West Indies.

2. Search for HTLV-I and LAV/HTLV-III antibodies in serum and CSF of multiple sclerosis patients.

3. Sera from patients with multiple sclerosis react with human cell T lymphotropic virus-I gag proteins but not env proteins--Western blotting analysis.

4. HTLV-III infection in brains of children and adults with AIDS encephalopathy.

5. Analysis of human T-lymphotrophic virus sequences in multiple sclerosis tissue.

6. Lack of evidence for involvement of known human retroviruses in multiple sclerosis.

7. Sera from adult T-cell leukemia patients react with envelope and core polypeptides of adult T-cell leukemia virus.

8. Detection of serum antibodies to adult T-cell leukemia virus in non-human primates and in people from Africa.

9. Multiple sclerosis and human T-cell lymphotropic retroviruses.

10. Absence of antibody to HTLV I and III in sera of Canadian patients with multiple sclerosis and chronic myelopathy.

1. Differential diagnosis of HTLV-I-associated myelopathy and multiple sclerosis in Iranian patients.

2. A soluble form of tumour necrosis factor receptor in cerebrospinal fluid and serum of HTLV-I-associated myelopathy and other neurological diseases.