PURPOSE: Catheter ablation for atrial fibrillation is performed with and without deep sedation, which could affect the arrhythmogenic activity during the procedure. We investigated the impact of sedation on electrophysiological properties in patients with AF who underwent catheter ablation. METHODS: This study consisted of 255 consecutive patients with atrial fibrillation (229 males, persistent: 105 patients) who underwent a single-catheter ablation procedure. The patients were divided into the following two groups according to the depth of sedation during the procedure: group M (mild sedation with flunitrazepam in 138 patients) and group D (deep sedation with propofol in 117 patients). Peripheral oxygen saturation was continuously monitored via pulse oximetry throughout the procedure. RESULTS: A spontaneous dissociated pulmonary vein activity after pulmonary vein isolation occurred more frequently in group M than in group D (29.1 vs 15.7%, P < 0.01). Adenosine-induced dormant pulmonary vein conduction was more frequently observed in group M than in group D (19.2 vs 13.0% P = 0.01). There were no significant differences in the incidence of non-pulmonary vein triggers between groups M and D (15.2 vs 11.1%, P = 0.53). The atrial fibrillation recurrence rate following the single procedure did not differ between the two groups (29.0 vs 26.5%, in groups M and D, P = 0.85). CONCLUSIONS: Although deep sedation reduced the incidence of a dissociated pulmonary vein activity and dormant pulmonary vein conduction following pulmonary vein isolation, it did not affect the recurrence rate for atrial fibrillation after the procedure.
PURPOSE: Catheter ablation for atrial fibrillation is performed with and without deep sedation, which could affect the arrhythmogenic activity during the procedure. We investigated the impact of sedation on electrophysiological properties in patients with AF who underwent catheter ablation. METHODS: This study consisted of 255 consecutive patients with atrial fibrillation (229 males, persistent: 105 patients) who underwent a single-catheter ablation procedure. The patients were divided into the following two groups according to the depth of sedation during the procedure: group M (mild sedation with flunitrazepam in 138 patients) and group D (deep sedation with propofol in 117 patients). Peripheral oxygen saturation was continuously monitored via pulse oximetry throughout the procedure. RESULTS: A spontaneous dissociated pulmonary vein activity after pulmonary vein isolation occurred more frequently in group M than in group D (29.1 vs 15.7%, P < 0.01). Adenosine-induced dormant pulmonary vein conduction was more frequently observed in group M than in group D (19.2 vs 13.0% P = 0.01). There were no significant differences in the incidence of non-pulmonary vein triggers between groups M and D (15.2 vs 11.1%, P = 0.53). The atrial fibrillation recurrence rate following the single procedure did not differ between the two groups (29.0 vs 26.5%, in groups M and D, P = 0.85). CONCLUSIONS: Although deep sedation reduced the incidence of a dissociated pulmonary vein activity and dormant pulmonary vein conduction following pulmonary vein isolation, it did not affect the recurrence rate for atrial fibrillation after the procedure.
Authors: Luigi Di Biase; Sergio Conti; Prasant Mohanty; Rong Bai; Javier Sanchez; David Walton; Annie John; Pasquale Santangeli; Claude S Elayi; Salwa Beheiry; G Joseph Gallinghouse; Sanghamitra Mohanty; Rodney Horton; Shane Bailey; J David Burkhardt; Andrea Natale Journal: Heart Rhythm Date: 2010-11-02 Impact factor: 6.343
Authors: Hans Kottkamp; Gerhard Hindricks; Charlotte Eitel; Kristin Müller; Angela Siedziako; Julia Koch; Maria Anastasiou-Nana; Christos Varounis; Arash Arya; Philipp Sommer; Thomas Gaspar; Christopher Piorkowski; Nikolaos Dagres Journal: J Cardiovasc Electrophysiol Date: 2011-06-21
Authors: Ka Hou Christien Li; Tian Sang; Cheng Chan; Mengqi Gong; Yingzhi Liu; Aaron Jesuthasan; Guangping Li; Tong Liu; Michael H S Lam; William Kk Wu; Matthew T V Chan; Fang-Zhou Liu; Cheng Chen; Jeffery Ho; Yunlong Xia; Gary Tse Journal: Heart Asia Date: 2019-08-14