| Literature DB >> 2828536 |
C B Dejean1, J R Oubiña, G Carballal, A R Teyssié.
Abstract
The interferon (IFN) induction capacity of the XJ prototype strain of Junín virus (JV) was investigated in the guinea pig model. Circulating alpha IFN was detected in 50% of the animals from days 2 to 9 postinfection (pi) and in 100% at day 11 pi, when all animals were in the premortem stage. Individual levels ranged from 20 to 1,280 guinea pig IFN units (GPIFNU)/ml. A correlation between XJ strain virulence and IFN titers was recorded. A possible role of IFN as a pathogenic factor in the outcome of the disease is discussed.Entities:
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Year: 1988 PMID： 2828536 DOI： 10.1002/jmv.1890240112
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 2.327