| Literature DB >> 28285320 |
Tongxing Song1,2, Yang Yang1,2, Yuanfei Zhou1,2, Hongkui Wei3,4, Jian Peng5,6.
Abstract
It is well known that adipose tissue has a critical role in the development of obesity and metabolic diseases and that adipose tissue acts as an endocrine organ to regulate lipid and glucose metabolism. Accumulating in the adipose tissue, fatty acids serve as a primary source of essential nutrients and act on intracellular and cell surface receptors to regulate biological events. G protein-coupled receptor 120 (GPR120) represents a promising target for the treatment of obesity-related metabolic disorders for its involvement in the regulation of adipogenesis, inflammation, glucose uptake, and insulin resistance. In this review, we summarize recent studies and advances regarding the systemic role of GPR120 in adipose tissue, including both white and brown adipocytes. We offer a new perspective by comparing the different roles in a variety of homeostatic processes from adipogenic development to adipocyte metabolism, and we also discuss the effects of natural and synthetic agonists that may be potential agents for the treatment of metabolic diseases.Entities:
Keywords: Adipogenesis; Brown adipose tissue; Fatty acids; GPR120; Glucose uptake; Metabolic homeostasis; White adipose tissue
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Year: 2017 PMID： 28285320 DOI： 10.1007/s00018-017-2492-2
Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261