Peter C Church1,2, Mary-Louise C Greer3, Ruth Cytter-Kuint3, Andrea S Doria4,3, Anne M Griffiths5,6, Dan Turner7, Thomas D Walters5,6, Brian M Feldman4,8. 1. Division of Gastroenterology, Hepatology & Nutrition, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Ave., Toronto, ON, Canada, M5G 1X8. peterchurch@gmail.com. 2. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada. peterchurch@gmail.com. 3. Department of Diagnostic Imaging, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, ON, Canada. 4. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada. 5. Division of Gastroenterology, Hepatology & Nutrition, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Ave., Toronto, ON, Canada, M5G 1X8. 6. SickKids Inflammatory Bowel Disease Center, The Hospital for Sick Children, Toronto, ON, Canada. 7. Shaare Zedek Medical Center, Jerusalem, Israel. 8. Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
Abstract
BACKGROUND: Magnetic resonance enterography (MRE) is increasingly relied upon for noninvasive assessment of intestinal inflammation in Crohn disease. However very few studies have examined the diagnostic accuracy of individual MRE signs in children. OBJECTIVE: We have created an MR-based multi-item measure of intestinal inflammation in children with Crohn disease - the Pediatric Inflammatory Crohn's MRE Index (PICMI). To inform item selection for this instrument, we explored the inter-rater agreement and diagnostic accuracy of individual MRE signs of inflammation in pediatric Crohn disease and compared our findings with the reference standards of the weighted Pediatric Crohn's Disease Activity Index (wPCDAI) and C-reactive protein (CRP). MATERIALS AND METHODS: In this cross-sectional single-center study, MRE studies in 48 children with diagnosed Crohn disease (66% male, median age 15.5 years) were reviewed by two independent radiologists for the presence of 15 MRE signs of inflammation. Using kappa statistics we explored inter-rater agreement for each MRE sign across 10 anatomical segments of the gastrointestinal tract. We correlated MRE signs with the reference standards using correlation coefficients. Radiologists measured the length of inflamed bowel in each segment of the gastrointestinal tract. In each segment, MRE signs were scored as either binary (0-absent, 1-present), or ordinal (0-absent, 1-mild, 2-marked). These segmental scores were weighted by the length of involved bowel and were summed to produce a weighted score per patient for each MRE sign. Using a combination of wPCDAI≥12.5 and CRP≥5 to define active inflammation, we calculated area under the receiver operating characteristic curve (AUC) for each weighted MRE sign. RESULTS: Bowel wall enhancement, wall T2 hyperintensity, wall thickening and wall diffusion-weighted imaging (DWI) hyperintensity were most commonly identified. Inter-rater agreement was best for decreased motility and wall DWI hyperintensity (kappa≥0.64). Correlation between MRE signs and wPCDAI was higher than with CRP. AUC was highest (≥0.75) for ulcers, wall enhancement, wall thickening, wall T2 hyperintensity and wall DWI hyperintensity. CONCLUSION: Some MRE signs had good inter-rater agreement and AUC for detection of inflammation in children with Crohn disease.
BACKGROUND: Magnetic resonance enterography (MRE) is increasingly relied upon for noninvasive assessment of intestinal inflammation in Crohn disease. However very few studies have examined the diagnostic accuracy of individual MRE signs in children. OBJECTIVE: We have created an MR-based multi-item measure of intestinal inflammation in children with Crohn disease - the Pediatric Inflammatory Crohn's MRE Index (PICMI). To inform item selection for this instrument, we explored the inter-rater agreement and diagnostic accuracy of individual MRE signs of inflammation in pediatric Crohn disease and compared our findings with the reference standards of the weighted Pediatric Crohn's Disease Activity Index (wPCDAI) and C-reactive protein (CRP). MATERIALS AND METHODS: In this cross-sectional single-center study, MRE studies in 48 children with diagnosed Crohn disease (66% male, median age 15.5 years) were reviewed by two independent radiologists for the presence of 15 MRE signs of inflammation. Using kappa statistics we explored inter-rater agreement for each MRE sign across 10 anatomical segments of the gastrointestinal tract. We correlated MRE signs with the reference standards using correlation coefficients. Radiologists measured the length of inflamed bowel in each segment of the gastrointestinal tract. In each segment, MRE signs were scored as either binary (0-absent, 1-present), or ordinal (0-absent, 1-mild, 2-marked). These segmental scores were weighted by the length of involved bowel and were summed to produce a weighted score per patient for each MRE sign. Using a combination of wPCDAI≥12.5 and CRP≥5 to define active inflammation, we calculated area under the receiver operating characteristic curve (AUC) for each weighted MRE sign. RESULTS:Bowel wall enhancement, wall T2 hyperintensity, wall thickening and wall diffusion-weighted imaging (DWI) hyperintensity were most commonly identified. Inter-rater agreement was best for decreased motility and wall DWI hyperintensity (kappa≥0.64). Correlation between MRE signs and wPCDAI was higher than with CRP. AUC was highest (≥0.75) for ulcers, wall enhancement, wall thickening, wall T2 hyperintensity and wall DWI hyperintensity. CONCLUSION: Some MRE signs had good inter-rater agreement and AUC for detection of inflammation in children with Crohn disease.
Entities:
Keywords:
Children; Crohn disease; Diagnostic accuracy; Inflammation; Magnetic resonance enterography; Magnetic resonance imaging
Authors: Karin Horsthuis; Lissy de Ridder; Anne M J B Smets; Maarten S van Leeuwen; Marc A Benninga; Roderick H J Houwen; Annemieke S Littooij; Rutger A J Nievelstein; Jaap Stoker Journal: J Pediatr Gastroenterol Nutr Date: 2010-11 Impact factor: 2.839
Authors: Jeffrey Hyams; James Markowitz; Anthony Otley; Joel Rosh; David Mack; Athos Bousvaros; Subra Kugathasan; M Pfefferkorn; Vasundhara Tolia; Jonathan Evans; William Treem; Robert Wyllie; Robert Rothbaum; J del Rosario; Aubrey Katz; Adam Mezoff; M Oliva-Hemker; Trudy Lerer; Anne Griffiths Journal: J Pediatr Gastroenterol Nutr Date: 2005-10 Impact factor: 2.839
Authors: Charlotte I de Bie; Stephan Buderus; Bhupinder K Sandhu; Lissy de Ridder; Anders Paerregaard; Gabor Veres; Jorge Amil Dias; Johanna C Escher Journal: J Pediatr Gastroenterol Nutr Date: 2012-03 Impact factor: 2.839
Authors: Fabian Schnitzler; Herma Fidder; Marc Ferrante; Maja Noman; Ingrid Arijs; Gert Van Assche; Ilse Hoffman; Kristel Van Steen; Séverine Vermeire; Paul Rutgeerts Journal: Inflamm Bowel Dis Date: 2009-09 Impact factor: 5.325
Authors: Jeroen A W Tielbeek; Mark Löwenberg; Shandra Bipat; Karin Horsthuis; Cyriel Y Ponsioen; Geert R D'Haens; Jaap Stoker Journal: Inflamm Bowel Dis Date: 2013-08 Impact factor: 5.325
Authors: Joy L Barber; Alexsandra Zambrano-Perez; Øystein E Olsen; Fevronia Kiparissi; Mila Baycheva; Daniela Knaflez; Neil Shah; Tom A Watson Journal: Pediatr Radiol Date: 2018-04-13
Authors: Bari Dane; Kun Qian; Simon Gauvin; Hoon Ji; Jay Karajgikar; Nancy Kim; Shannon Chang; Hersh Chandarana; Sooah Kim Journal: Abdom Radiol (NY) Date: 2021-07-29