Sonny Bherwani1, Ashok Kumar Ahirwar2, A S Saumya3, A S Sandhya4, Brijesh Prajapat5, Sitendu Patel6, Srushtee Bipin Jibhkate7, Ritu Singh8, L H Ghotekar9. 1. Department of Accident and Emergency Medicine, Lady Hardinge Medical College (LHMC), New Delhi, India. Electronic address: sunny86lhmc@gmail.com. 2. Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India. Electronic address: drashoklhmc@gmail.com. 3. Department of Pathology, Lady Hardinge Medical College (LHMC), New Delhi, India. Electronic address: nair.saumya06@gmail.com. 4. Department of Chest and TB, PGIMS, Rhotak, Haryana, India. Electronic address: dr.nair.sandhya@gmail.com. 5. Department of Pulmonary and Critical Care, PGIMS, Rhotak, Haryana, India. Electronic address: dr.brijeshprajapat@gmail.com. 6. Max Super Specialty Hospital, Saket, New Delhi, India. Electronic address: situssmc@gmail.com. 7. Department of Biochemistry, LN Medical College and JK Hospital, Bhopal, MP, India. Electronic address: srushteeghate@gmail.com. 8. Department of Biochemistry, Lady Hardinge Medical College (LHMC), New Delhi, India. Electronic address: drritusingh19@gmail.com. 9. Department of Medicine, Lady Hardinge Medical College (LHMC), New Delhi, India. Electronic address: rajghotekar@rediffmail.com.
Abstract
AIM: Diabetic Mellitus is the chronic metabolic disorder associated with various complications of heart, eyes, nerves, kidney etc. Diabetic Nephropathy is one of the leading causes of death in diabetic patient. We hypothesized that decrease Vitamin B12 levels is associated with Diabetic Nephropathy. Aim of our study is to study the serum Vitamin B12 levels in type 2 diabetes mellitus patients with and without nephropathy. METHODS: Our study population consist of 100 subjects out of which 50 cases of Diabetes Mellitus without Diabetic Nephropathy and 50 cases of Diabetes Mellitus with Diabetic Nephropathy. We measured various routine lab parameters, apart from it, we measured spot urinary albumin to creatinine ratio to assess diabetic nephropathy and in special investigation we measured serum Vitamin B12 by chemiluminesence based immunoassay. RESULT: Serum Vitamin B12 level in the group with nephropathy (181.6±17.6pg/dl) was significantly lower than in the group without nephropathy (286±30.1pg/dl) (p=0.03). CONCLUSION: Our study points towards the decrease levels of serum Vitamin B12 levels associated with the complication of diabetic mellitus such as diabetic nephropathy. So treatment of Vitamin B12 deficiency by supplementing could prevent the development and progression of diabetic nephropathy and improves the overall management of diabetic patient.
AIM: Diabetic Mellitus is the chronic metabolic disorder associated with various complications of heart, eyes, nerves, kidney etc. Diabetic Nephropathy is one of the leading causes of death in diabeticpatient. We hypothesized that decrease Vitamin B12 levels is associated with Diabetic Nephropathy. Aim of our study is to study the serum Vitamin B12 levels in type 2 diabetes mellituspatients with and without nephropathy. METHODS: Our study population consist of 100 subjects out of which 50 cases of Diabetes Mellitus without Diabetic Nephropathy and 50 cases of Diabetes Mellitus with Diabetic Nephropathy. We measured various routine lab parameters, apart from it, we measured spot urinary albumin to creatinine ratio to assess diabetic nephropathy and in special investigation we measured serum Vitamin B12 by chemiluminesence based immunoassay. RESULT: Serum Vitamin B12 level in the group with nephropathy (181.6±17.6pg/dl) was significantly lower than in the group without nephropathy (286±30.1pg/dl) (p=0.03). CONCLUSION: Our study points towards the decrease levels of serum Vitamin B12 levels associated with the complication of diabetic mellitus such as diabetic nephropathy. So treatment of Vitamin B12 deficiency by supplementing could prevent the development and progression of diabetic nephropathy and improves the overall management of diabeticpatient.