Sang Jun Park1, Hyun Jung Kim2, Hojong Park1, Hoo Jae Hann3, Kyoung Hoon Kim4, Seungjin Han4, Yuri Kim4, Hyeong Sik Ahn5. 1. Department of Surgery, University of Ulsan College of Medicine, Republic of Korea. 2. Department of Preventive Medicine, College of Medicine, Korea University, Republic of Korea. 3. Medical Research Institute, Ewha Womans University, Republic of Korea. Electronic address: ewhaebm@gmail.com. 4. Department of Public Health, Graduate School, Korea University, Republic of Korea. 5. Department of Preventive Medicine, College of Medicine, Korea University, Republic of Korea. Electronic address: iebm.ku@gmail.com.
Abstract
BACKGROUND: Studies investigating the epidemiology and mortality of Takayasu Arteritis (TA) are scarce. The objective of this study was to provide information regarding the epidemiology of TA, such as the incidence, prevalence, survival and cause of death in Korea. METHODS: We used a national, population-based database maintained by the Rare Intractable Disease registration program and the Health Insurance Review and Assessment Service, which includes information on all TA patients, diagnosed based on uniform criteria. We also used data from Statistics Korea linked with RID database to confirm survival and cause of death. We analyzed data for the period 2008-2012. RESULTS: During study period, there were 612 new patients with TA, with a female-to-male ratio of 4.3:1. The annual mean incidence was 0.24 per 105 people, and the prevalence was 2.82 per 105 people in 2012. The average annual mortality rate was 0.02 per 105 people, and the standardized mortality ratio was 3.1. The overall survival of patients with TA was 96.6%, which was significantly lower than that in the general population. Cardiovascular disease was the most common cause of death, accounting for 29 of the 64 deaths (45.3%), followed by neoplasms in 9 patients (14.1%). CONCLUSIONS: The incidence and prevalence presented in this study are the highest ever reported. The survival of patients with TA was significantly lower than that of the general population, and the main cause of death was cardiovascular disease. This study reflects the need for greater awareness of TA, especially in Asian countries.
BACKGROUND: Studies investigating the epidemiology and mortality of Takayasu Arteritis (TA) are scarce. The objective of this study was to provide information regarding the epidemiology of TA, such as the incidence, prevalence, survival and cause of death in Korea. METHODS: We used a national, population-based database maintained by the Rare Intractable Disease registration program and the Health Insurance Review and Assessment Service, which includes information on all TA patients, diagnosed based on uniform criteria. We also used data from Statistics Korea linked with RID database to confirm survival and cause of death. We analyzed data for the period 2008-2012. RESULTS: During study period, there were 612 new patients with TA, with a female-to-male ratio of 4.3:1. The annual mean incidence was 0.24 per 105 people, and the prevalence was 2.82 per 105 people in 2012. The average annual mortality rate was 0.02 per 105 people, and the standardized mortality ratio was 3.1. The overall survival of patients with TA was 96.6%, which was significantly lower than that in the general population. Cardiovascular disease was the most common cause of death, accounting for 29 of the 64 deaths (45.3%), followed by neoplasms in 9 patients (14.1%). CONCLUSIONS: The incidence and prevalence presented in this study are the highest ever reported. The survival of patients with TA was significantly lower than that of the general population, and the main cause of death was cardiovascular disease. This study reflects the need for greater awareness of TA, especially in Asian countries.
Authors: Dan Pugh; Maira Karabayas; Neil Basu; Maria C Cid; Ruchika Goel; Carl S Goodyear; Peter C Grayson; Stephen P McAdoo; Justin C Mason; Catherine Owen; Cornelia M Weyand; Taryn Youngstein; Neeraj Dhaun Journal: Nat Rev Dis Primers Date: 2022-01-06 Impact factor: 65.038
Authors: Ruchika Goel; K Bates Gribbons; Simon Carette; David Cuthbertson; Gary S Hoffman; George Joseph; Nader A Khalidi; Curry L Koening; Sathish Kumar; Carol Langford; Kathleen Maksimowicz-McKinnon; Carol A McAlear; Paul A Monach; Larry W Moreland; Aswin Nair; Christian Pagnoux; Kaitlin A Quinn; Raheesh Ravindran; Philip Seo; Antoine G Sreih; Kenneth J Warrington; Steven R Ytterberg; Peter A Merkel; Debashish Danda; Peter C Grayson Journal: Rheumatology (Oxford) Date: 2020-05-01 Impact factor: 7.580
Authors: Stella Pui Yan Wong; Chi Chiu Mok; Chak Sing Lau; Man Lung Yip; Lai Shan Tam; King Yee Ying; Woon Leung Ng; Kam Hung Ng; Moon Ho Leung; Tsz Yan Lee; Chi Hung To; Ka Lai Lee; Man Choi Wan; Ka Lung Yu; Priscilla Ching Han Wong; Chi Keung Sung; Kwok Fai Lee; Emily Wai Lin Kun Journal: Rheumatol Int Date: 2018-09-04 Impact factor: 2.631
Authors: Jolanta Dadonienė; Greta Charukevič; Gabija Jasionytė; Karolina Staškuvienė; Dalia Miltinienė Journal: Int J Environ Res Public Health Date: 2021-11-24 Impact factor: 3.390