Viviana Loria-Kohen1, Helena Marcos-Pasero2, Rocío de la Iglesia2, Elena Aguilar-Aguilar2, Isabel Espinosa-Salinas2, Jesús Herranz2, Ana Ramírez de Molina2, Guillermo Reglero3. 1. IMDEA-Food, Campus de Excelencia Internacional (CEI) UAM+CSIC, Madrid, España. Electronic address: viviana.loria@imdea.org. 2. IMDEA-Food, Campus de Excelencia Internacional (CEI) UAM+CSIC, Madrid, España. 3. IMDEA-Food, Campus de Excelencia Internacional (CEI) UAM+CSIC, Madrid, España; Departamento de Producción y Caracterización de Nuevos Alimentos, Instituto de Investigación en Ciencias de la Alimentación (CIAL), Campus de Excelencia Internacional (CEI) UAM+CSIC, Madrid, España.
Abstract
BACKGROUND AND OBJECTIVES: Multiple chemical sensitivity (MCS) is a chronic, multisystem syndrome of unknown etiology. The aim of the present study was to describe the nutritional status and quality of life of patients suffering from MCS, as well as to identify potential polymorphisms associated with this illness. PATIENTS AND METHODS: A cross-sectional, descriptive study was performed on patients with a diagnosis of MCS. Data on anthropometric and body composition variables, hand muscle strength and quality of life were collected. The selection of single nucleotide polymorphisms (SNPs) was based on genes previously associated with MCS and genes involved in inflammatory and oxidative stress pathways. RESULTS: A total of 52 patients (93.2% female), with a mean age of 50.9 (10.3) years were included in the study. Among them, based on their BMI, 48% had an inadequate nutritional status (17% were underweight and 32% were overweight or obese). Thirty percent of patients had a low muscle mass for their age, 84% had muscle strength below the tenth percentile, and 51.8% had a high fat mass percentage. Regarding quality of life, all median scores were lower than those of other illnesses assessed for every subscale assessed. Statistically significant differences between patient cases and controls were found with respect to rs1801133 (MTHFR), rs174546 (FADS1) and rs1801282 (PPARγ) polymorphisms. CONCLUSION: A high percentage of patients had a poor nutritional status, low muscle strength and decreased muscle mass. These facts exacerbate the already-lower quality of life of these patients. Specific genetic polymorphisms associated with the syndrome or its pathogenesis were not identified.
BACKGROUND AND OBJECTIVES: Multiple chemical sensitivity (MCS) is a chronic, multisystem syndrome of unknown etiology. The aim of the present study was to describe the nutritional status and quality of life of patients suffering from MCS, as well as to identify potential polymorphisms associated with this illness. PATIENTS AND METHODS: A cross-sectional, descriptive study was performed on patients with a diagnosis of MCS. Data on anthropometric and body composition variables, hand muscle strength and quality of life were collected. The selection of single nucleotide polymorphisms (SNPs) was based on genes previously associated with MCS and genes involved in inflammatory and oxidative stress pathways. RESULTS: A total of 52 patients (93.2% female), with a mean age of 50.9 (10.3) years were included in the study. Among them, based on their BMI, 48% had an inadequate nutritional status (17% were underweight and 32% were overweight or obese). Thirty percent of patients had a low muscle mass for their age, 84% had muscle strength below the tenth percentile, and 51.8% had a high fat mass percentage. Regarding quality of life, all median scores were lower than those of other illnesses assessed for every subscale assessed. Statistically significant differences between patient cases and controls were found with respect to rs1801133 (MTHFR), rs174546 (FADS1) and rs1801282 (PPARγ) polymorphisms. CONCLUSION: A high percentage of patients had a poor nutritional status, low muscle strength and decreased muscle mass. These facts exacerbate the already-lower quality of life of these patients. Specific genetic polymorphisms associated with the syndrome or its pathogenesis were not identified.
Authors: Christa Watson-Wright; Priscila Queiroz; Sylvia Rodrigues; Thomas C Donaghey; Joseph D Brain; Ramon M Molina Journal: Exp Lung Res Date: 2018-10-08 Impact factor: 2.459
Authors: Anne A Bjerregaard; Marie W Petersen; Sine Skovbjerg; Lise K Gormsen; José G Cedeño-Laurent; Torben Jørgensen; Allan Linneberg; Thomas Meinertz Dantoft Journal: Int J Environ Res Public Health Date: 2022-07-25 Impact factor: 4.614