Emilio Pariente-Rodrigo1, Giusi Alessia Sgaramella2, José Manuel Olmos-Martínez3, Stefanie Francesca Pini-Valdivieso4, Rosa Landeras-Alvaro5, José Luis Hernández-Hernández3. 1. Medicina de Familia, EAP Camargo-Interior, Servicio Cántabro de Salud-Observatorio de Salud Pública de Cantabria, Muriedas, Cantabria, España. Electronic address: emilio.pariente@scsalud.es. 2. Servicio de Hospitalización Domiciliaria, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, España. 3. Unidad de Metabolismo Óseo, Servicio de Medicina Interna, Hospital Universitario Marqués de Valdecilla-IDIVAL, RETICEF, Santander, Cantabria, España. 4. Medicina de Familia, EAP Camargo-Interior, Servicio Cántabro de Salud-Observatorio de Salud Pública de Cantabria, Muriedas, Cantabria, España. 5. Sección de Radiología Ósea, Servicio de Radiodiagnóstico, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, España.
Abstract
BACKGROUND AND OBJECTIVE: Diffuse idiopathic skeletal hyperostosis (DISH) and abdominal aortic calcification (AAC) are related to an increased cardiovascular risk. The aim of this study was to analyse a possible relationship between both entities and also the association between metabolic disorders and DISH. PATIENTS AND METHOD: Analytic cross-sectional study in a population-based cohort. DISH (with Resnick-Niwayama criteria) and AAC (with AAC-24 scale) were assessed on plain x-ray images. Interaction terms between DISH and forty clinical covariates were also investigated, through correlation analysis and multivariate regression. RESULTS: Nine hundred eighty-seven males aged≥50 years, with a mean age=65,5±9 years, were evaluated. Prevalence rates of DISH and AAC were 21.6% and 58.7%, respectively. DISH+ subjects were older (68.1±9 vs. 63.8±9 years; P=.0001) and more likely to be affected by metabolic syndrome (MS) (55.6% vs. 36.6%; P=.0001). In DISH+ subjects, the AAC was 3.7±5 points, whereas in DISH- subjects it was 3.3±5 (P=.25). AAC was associated with an increased risk of prevalent DISH (unadjusted OR=1.4 [CI95%: 1.01-1.9]; P=.04), that disappeared when it was adjusted for age (adjusted OR=1.1 [CI95%: 0.8-1.5];P=.47]. No association was found between DISH and hypertension, diabetes or dyslipidaemia; however, age (OR=2.2 [CI95%: 1.6-3]; P=.0001), BMI (OR=1.5 [CI95%: 1.1-2]; P=.007), waist circumference (OR=1.5 [CI95%: 1.04-2,3]; P=.03) and MS (OR=1.7 [CI95%: 1.1-2.4]; P=.005) showed a significant relationship with DISH after adjusting for confounders. CONCLUSIONS: The study was not able to demonstrate a consistent association between DISH and AAC, proving only a weak and age-dependent relationship between them. DISH proved to be significantly associated with age, BMI, waist circumference and MS.
BACKGROUND AND OBJECTIVE: Diffuse idiopathic skeletal hyperostosis (DISH) and abdominal aortic calcification (AAC) are related to an increased cardiovascular risk. The aim of this study was to analyse a possible relationship between both entities and also the association between metabolic disorders and DISH. PATIENTS AND METHOD: Analytic cross-sectional study in a population-based cohort. DISH (with Resnick-Niwayama criteria) and AAC (with AAC-24 scale) were assessed on plain x-ray images. Interaction terms between DISH and forty clinical covariates were also investigated, through correlation analysis and multivariate regression. RESULTS: Nine hundred eighty-seven males aged≥50 years, with a mean age=65,5±9 years, were evaluated. Prevalence rates of DISH and AAC were 21.6% and 58.7%, respectively. DISH+ subjects were older (68.1±9 vs. 63.8±9 years; P=.0001) and more likely to be affected by metabolic syndrome (MS) (55.6% vs. 36.6%; P=.0001). In DISH+ subjects, the AAC was 3.7±5 points, whereas in DISH- subjects it was 3.3±5 (P=.25). AAC was associated with an increased risk of prevalent DISH (unadjusted OR=1.4 [CI95%: 1.01-1.9]; P=.04), that disappeared when it was adjusted for age (adjusted OR=1.1 [CI95%: 0.8-1.5];P=.47]. No association was found between DISH and hypertension, diabetes or dyslipidaemia; however, age (OR=2.2 [CI95%: 1.6-3]; P=.0001), BMI (OR=1.5 [CI95%: 1.1-2]; P=.007), waist circumference (OR=1.5 [CI95%: 1.04-2,3]; P=.03) and MS (OR=1.7 [CI95%: 1.1-2.4]; P=.005) showed a significant relationship with DISH after adjusting for confounders. CONCLUSIONS: The study was not able to demonstrate a consistent association between DISH and AAC, proving only a weak and age-dependent relationship between them. DISH proved to be significantly associated with age, BMI, waist circumference and MS.
Authors: A B Auðunsson; G J Elíasson; E Steingrímsson; T Aspelund; S Sigurdsson; L Launer; V Gudnason; H Jonsson Journal: Scand J Rheumatol Date: 2021-03-07 Impact factor: 3.057
Authors: Sacha Kacki; Petr Velemínský; Niels Lynnerup; Sylva Kaupová; Alizé Lacoste Jeanson; Ctibor Povýšil; Martin Horák; Jan Kučera; Kaare Lund Rasmussen; Jaroslav Podliska; Zdeněk Dragoun; Jiří Smolík; Jens Vellev; Jaroslav Brůžek Journal: PLoS One Date: 2018-04-19 Impact factor: 3.240
Authors: Netanja I Harlianto; Jan Westerink; Marjolein E Hol; Rianne Wittenberg; Wouter Foppen; Pieternella H van der Veen; Bram van Ginneken; Jorrit-Jan Verlaan; Pim A de Jong; Firdaus A A Mohamed Hoesein Journal: Rheumatol Adv Pract Date: 2022-08-10
Authors: Netanja I Harlianto; Nadine Oosterhof; Wouter Foppen; Marjolein E Hol; Rianne Wittenberg; Pieternella H van der Veen; Bram van Ginneken; Firdaus A A Mohamed Hoesein; Jorrit-Jan Verlaan; Pim A de Jong; Jan Westerink Journal: Rheumatology (Oxford) Date: 2022-07-06 Impact factor: 7.046