Literature DB >> 2828222

Alterations of class I HLA genes in human colon cancers.

M Bar-Eli1, H Battifora, M J Cline.   

Abstract

Alterations of HLA class I genes were found in 3 of 12 human colon cancers. Rearrangements in HLA class I genes were observed in 2 cancers and amplification of HLA-coding genes was observed in 1 cancer. All 3 cancers were at an advanced stage. No examples of amplification or rearrangement in the HLA genes were found in 10 other tumours of diverse types. No alterations in the beta 2-microglobulin gene were observed in 22 human solid tumours included in this study. The association between alterations in HLA genes and proto-oncogenes in these tumours is discussed.

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Year:  1988        PMID： 2828222     DOI： 10.1007/BF00291242

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  28 in total

1.  Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer.

Authors:  A K Sood; D Pereira; S M Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

2.  Polymorphic restriction endonuclease fragment segregates and correlates with the gene for HLA-B8.

Authors:  H M Cann; L Ascanio; P Paul; A Marcadet; J Dausset; D Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

3.  The major histocompatibility complex in man.

Authors:  J Dausset
Journal:  Science       Date:  1981-09-25       Impact factor: 47.728

Review 4.  Ia antigens as restriction molecules in Ir-gene controlled T-cell proliferation.

Authors:  Z A Nagy; C N Baxevanis; N Ishii; J Klein
Journal:  Immunol Rev       Date:  1981       Impact factor: 12.988

5.  Loss of beta2 microglobulin from the cell surface of cutaneous malignant and premalignant lesions.

Authors:  M L Turbitt; R M Mackie
Journal:  Br J Dermatol       Date:  1981-05       Impact factor: 9.302

6.  Loss of HLA-A,B,C and de novo expression of HLA-D in colorectal cancer.

Authors:  F Momburg; T Degener; E Bacchus; G Moldenhauer; G J Hämmerling; P Möller
Journal:  Int J Cancer       Date:  1986-02-15       Impact factor: 7.396

7.  Immunohistologic characterization of major histocompatibility antigens and inflammatory cellular infiltrate in human breast cancer.

Authors:  A K Bhan; C L DesMarais
Journal:  J Natl Cancer Inst       Date:  1983-09       Impact factor: 13.506

8.  Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection.

Authors:  R Wallich; N Bulbuc; G J Hämmerling; S Katzav; S Segal; M Feldman
Journal:  Nature       Date:  1985 May 23-29       Impact factor: 49.962

9.  Expression of histocompatibility antigens and characterization of mononuclear cell infiltrates in normal and neoplastic colorectal tissues of humans.

Authors:  H C Umpleby; D Heinemann; M O Symes; R C Williamson
Journal:  J Natl Cancer Inst       Date:  1985-06       Impact factor: 13.506

10.  Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo.

Authors:  J Yokota; T Yamamoto; K Toyoshima; M Terada; T Sugimura; H Battifora; M J Cline
Journal:  Lancet       Date:  1986-04-05       Impact factor: 79.321
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  2 in total

Review 1.  The bodies fight against cancer: is human leucocyte antigen (HLA) class 1 the key?

Authors:  Arfon G M T Powell; Paul G Horgan; Joanne Edwards
Journal:  J Cancer Res Clin Oncol       Date:  2012-03-18       Impact factor: 4.553

2.  HLA class I gene expression on human primary tumours and autologous metastases: demonstration of selective losses of HLA antigens on colorectal, gastric and laryngeal carcinomas.

Authors:  M A López-Nevot; F Esteban; A Ferrón; J Gutiérrez; M R Oliva; C Romero; C Huelin; F Ruiz-Cabello; F Garrido
Journal:  Br J Cancer       Date:  1989-02       Impact factor: 7.640
  2 in total

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