Hiurma Sánchez-Pérez1, Beatriz Tejera-Segura1, Antonia de Vera-González2, Alejandra González-Delgado2, José Manuel Olmos3, José Luis Hernández3, Alfonso Corrales4, Raquel López-Mejías5, Miguel Angel González-Gay6, Iván Ferraz-Amaro7. 1. Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain. 2. Central Laboratory Division, Hospital Universitario de Canarias, Tenerife, Spain. 3. Division of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, RETICEF; and School of Medicine, University of Cantabria, Santander, Spain. 4. Div. of Rheumatology, Hosp.Univ. Marqués de Valdecilla, IDIVAL, School of Medicine, Univ.of Cantabria; and Epidemiology, Genetics and Atherosclerosis Res. Group on Systemic Inflammatory Diseases, Hosp.Univ. Marqués de Valdecilla, IDIVAL, Santander, Spain. 5. Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain. 6. Division of Rheumatology, Hosp. Universitario Marqués de Valdecilla, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain; and Cardiovascular Pathophysiology & Genomics Research Unit, Univ.of the Witwatersrand, Johannesburg, South Africa. 7. Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain. iferrazamaro@hotmail.com.
Abstract
OBJECTIVES: Insulin resistance (IR) plays a role in the increased cardiovascular risk of systemic lupus erythematosus (SLE) patients. This study aimed to determine the potential association of IR with disease activity, drug exposure and subclinical atherosclerosis in patients with SLE. METHODS: This cross-sectional study encompassed 87 non-diabetic SLE patients and 82 sex-matched controls. Insulin and C-peptide serum levels, IR indexes by homeostatic model assessment (HOMA2) (both insulin-based: HOMA2-IR, and with C-peptide: HOMA2-IR-C-peptide) and lipid profiles were assessed in patients and controls. Activity (SLEDAI), severity (Katz) and damage (SLICC) index scores, as well as carotid intima-media thickness (cIMT) and carotid plaques, were determined in SLE patients. A multivariable regression analysis, adjusted for classic IR related factors, was performed to evaluate the differences in IR indexes between patients and controls and how IR is associated with disease-related characteristics, including carotid ultrasound results, in SLE patients. RESULTS: SLE patients had higher C-peptide serum levels (2.61±1.51 vs. 1.34±0.62 ng/ml, p=0.00) and elevated HOMA2-IRC-peptide index (1.90±1.12 vs. 0.97±0.45, p=0.00) than controls. These differences remained statistically significant after adjusting for classic cardiovascular risk factors and prednisone intake. Traditional IR-related factors, such as body mass index, waist circumference or hypertension, and prednisone intake were significantly associated with HOMA2-IR and HOMA2-IRC-peptide in SLE patients. SLICC damage index was independently associated with HOMA2-IR-C-peptide. The presence of carotid plaques and cIMT values were associated with IR indexes in SLE patients only in the univariate analysis. CONCLUSIONS: C-peptide serum levels are independently up-regulated in SLE patients. Although classic IR factors and prednisone are associated with IR, SLE damage over time also contributes to IR in an independent way.
OBJECTIVES:Insulin resistance (IR) plays a role in the increased cardiovascular risk of systemic lupus erythematosus (SLE) patients. This study aimed to determine the potential association of IR with disease activity, drug exposure and subclinical atherosclerosis in patients with SLE. METHODS: This cross-sectional study encompassed 87 non-diabetic SLEpatients and 82 sex-matched controls. Insulin and C-peptide serum levels, IR indexes by homeostatic model assessment (HOMA2) (both insulin-based: HOMA2-IR, and with C-peptide: HOMA2-IR-C-peptide) and lipid profiles were assessed in patients and controls. Activity (SLEDAI), severity (Katz) and damage (SLICC) index scores, as well as carotid intima-media thickness (cIMT) and carotid plaques, were determined in SLEpatients. A multivariable regression analysis, adjusted for classic IR related factors, was performed to evaluate the differences in IR indexes between patients and controls and how IR is associated with disease-related characteristics, including carotid ultrasound results, in SLEpatients. RESULTS:SLEpatients had higher C-peptide serum levels (2.61±1.51 vs. 1.34±0.62 ng/ml, p=0.00) and elevated HOMA2-IRC-peptide index (1.90±1.12 vs. 0.97±0.45, p=0.00) than controls. These differences remained statistically significant after adjusting for classic cardiovascular risk factors and prednisone intake. Traditional IR-related factors, such as body mass index, waist circumference or hypertension, and prednisone intake were significantly associated with HOMA2-IR and HOMA2-IRC-peptide in SLEpatients. SLICC damage index was independently associated with HOMA2-IR-C-peptide. The presence of carotid plaques and cIMT values were associated with IR indexes in SLEpatients only in the univariate analysis. CONCLUSIONS: C-peptide serum levels are independently up-regulated in SLEpatients. Although classic IR factors and prednisone are associated with IR, SLE damage over time also contributes to IR in an independent way.
Authors: Seung Mi Lee; Eun Mi Lee; Jin Kyun Park; Hae Sun Jeon; Sohee Oh; Subeen Hong; Young Mi Jung; Byoung Jae Kim; Sun Min Kim; Errol R Norwitz; Eun Bong Lee; Souphaphone Louangsenlath; Chan-Wook Park; Jong Kwan Jun; Joong Shin Park; Do Yup Lee Journal: Sci Rep Date: 2019-10-23 Impact factor: 4.379
Authors: Apinya Lertratanakul; Julia Sun; Peggy W Wu; Jungwha Lee; Alan Dyer; William Pearce; David McPherson; Kim Sutton-Tyrrell; Trina Thompson; Emma Barinas-Mitchell; Rosalind Ramsey-Goldman Journal: Lupus Sci Med Date: 2021-12