Literature DB >> 28281084

The role and clinical implications of the endosteal niche and osteoblasts in regulating leukemia.

S Azizidoost1, V Vijay2, C R Cogle2, E Khodadi3, N Saki4.   

Abstract

Osteoblasts are one among the critical components of the endosteal bone marrow (BM) niche. In addition to hematopoietic stem cell fate, their role in leukemogenesis as well as metastasis of a variety of cancers has been demonstrated in various studies. In this regard, endosteal niche can have a dual role as an initiator and protective role against leukemia. Knowledge of growth factors, chemokines and cytokines secreted by osteoblasts as well as their interaction with signaling pathways inform our understanding of the development, prognosis, recurrence and treatment of malignant BM diseases. Clinical progress in targeting the endosteal niche is also discussed.

Entities:  

Keywords:  Chemokine; Endosteal niche; Osteoblast; Quiescence; Therapy

Mesh：

Year:  2017        PMID： 28281084     DOI： 10.1007/s12094-017-1642-1

Source DB:  PubMed          Journal:  Clin Transl Oncol        ISSN： 1699-048X            Impact factor:   3.405


  63 in total

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Authors:  Geoffrey L Uy; Michael P Rettig; Ibraheem H Motabi; Kyle McFarland; Kathryn M Trinkaus; Lindsay M Hladnik; Shashikant Kulkarni; Camille N Abboud; Amanda F Cashen; Keith E Stockerl-Goldstein; Ravi Vij; Peter Westervelt; John F DiPersio
Journal:  Blood       Date:  2012-02-02       Impact factor: 22.113

2.  Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation.

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Journal:  Nat Med       Date:  2008-02-24       Impact factor: 53.440

Review 3.  Bone marrow niche in immune thrombocytopenia: a focus on megakaryopoiesis.

Authors:  Elaheh Khodadi; Ali Amin Asnafi; Saeid Shahrabi; Mohammad Shahjahani; Najmaldin Saki
Journal:  Ann Hematol       Date:  2016-05-28       Impact factor: 3.673

Review 4.  Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration.

Authors:  Bruno C Huber; Ulrich Grabmaier; Stefan Brunner
Journal:  World J Stem Cells       Date:  2014-11-26       Impact factor: 5.326

5.  Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.

Authors:  Peggy Kirstetter; Kristina Anderson; Bo T Porse; Sten Eirik W Jacobsen; Claus Nerlov
Journal:  Nat Immunol       Date:  2006-09-03       Impact factor: 25.606

6.  Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins.

Authors:  M Konopleva; S Konoplev; W Hu; A Y Zaritskey; B V Afanasiev; M Andreeff
Journal:  Leukemia       Date:  2002-09       Impact factor: 11.528

7.  Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.

Authors:  Fumio Arai; Atsushi Hirao; Masako Ohmura; Hidetaka Sato; Sahoko Matsuoka; Keiyo Takubo; Keisuke Ito; Gou Young Koh; Toshio Suda
Journal:  Cell       Date:  2004-07-23       Impact factor: 41.582

Review 8.  The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes.

Authors:  Azra Raza; Naomi Galili
Journal:  Nat Rev Cancer       Date:  2012-12       Impact factor: 60.716

9.  Redox modulation of adjacent thiols in VLA-4 by AS101 converts myeloid leukemia cells from a drug-resistant to drug-sensitive state.

Authors:  Adi Layani-Bazar; Itai Skornick; Alain Berrebi; Maor H Pauker; Elad Noy; Alon Silberman; Michael Albeck; Dan L Longo; Yona Kalechman; Benjamin Sredni
Journal:  Cancer Res       Date:  2014-04-03       Impact factor: 12.701

10.  Acute Lymphoblastic Leukemia Cells Inhibit the Differentiation of Bone Mesenchymal Stem Cells into Osteoblasts In Vitro by Activating Notch Signaling.

Authors:  Gui-Cun Yang; You-Hua Xu; Hong-Xia Chen; Xiao-Jing Wang
Journal:  Stem Cells Int       Date:  2015-08-03       Impact factor: 5.443
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  4 in total

1.  Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches.

Authors:  Andrés García-García; Thibaut Klein; Gordian Born; Morgane Hilpert; Arnaud Scherberich; Claudia Lengerke; Radek C Skoda; Paul E Bourgine; Ivan Martin
Journal:  Proc Natl Acad Sci U S A       Date:  2021-10-05       Impact factor: 11.205

2.  Reciprocal Interactions of Leukemic Cells with Bone Marrow Stromal Cells Promote Enrichment of Leukemic Stem Cell Compartments in Response to Curcumin and Daunorubicin

Authors:  Saeed Mohammadi; Mohsen Nikbakht; Seyed Mehdi Sajjadi; Fariba Rad; Bahram Chahardouli; Javid Sabour Takanlu; Shahrbano Rostami; Kamran Alimoghaddam; Ardeshir Ghavamzadeh; Seyed H Ghaffari
Journal:  Asian Pac J Cancer Prev       Date:  2017-03-01

Review 3.  Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side.

Authors:  Rodrigo Prieto-Bermejo; Marta Romo-González; Alejandro Pérez-Fernández; Carla Ijurko; Ángel Hernández-Hernández
Journal:  J Exp Clin Cancer Res       Date:  2018-06-26

4.  MiR-425 expression profiling in acute myeloid leukemia might guide the treatment choice between allogeneic transplantation and chemotherapy.

Authors:  Chen Yang; Tingting Shao; Huihui Zhang; Ninghan Zhang; Xiaoying Shi; Xuejiao Liu; Yao Yao; Linyan Xu; Shengyun Zhu; Jiang Cao; Hai Cheng; Zhiling Yan; Zhenyu Li; Mingshan Niu; Kailin Xu
Journal:  J Transl Med       Date:  2018-10-01       Impact factor: 5.531
  4 in total

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