Literature DB >> 28280630

The role of chemotherapy in gastric cancer-related microangiopathic haemolytic anaemia.

Monica Tang1, David Goldstein1.   

Abstract

We report a case of a previously well 46-year-old man who presented with microangiopathic haemolytic anaemia (MAHA) of unknown origin. After extensive investigations, he was diagnosed with cancer-related microangiopathic haemolytic anaemia (CR-MAHA) secondary to gastric adenocarcinoma. Initial treatment with plasmapheresis was ineffective, but the patient's haematological abnormalities improved markedly with chemotherapy directed against his gastric cancer. Our case amplifies previous experience of gastric cancer-associated MAHA which responded to treatment with chemotherapy. We review current understanding of the proposed pathophysiology of CR-MAHA and conclude that this condition is ideally treated with chemotherapy.

Entities:  

Keywords:  Thrombotic microangiopathies; anemia; drug therapy; hemolytic; stomach neoplasms; thrombocytopenia

Year:  2017        PMID： 28280630      PMCID： PMC5334044          DOI： 10.21037/jgo.2016.11.14

Source DB:  PubMed          Journal:  J Gastrointest Oncol        ISSN： 2078-6891


  23 in total

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Review 7.  Disseminated carcinoma diagnosed by bone marrow biopsy in patients with microangiopathic hemolytic anemia and thrombocytopenia: a report of two cases with gastric cancer and a review of the literature.

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  1 in total

1.  Microangiopathic hemolytic anemia as initial presentation of recurrent colon cancer.

Authors:  Joowon Park
Journal:  Blood Res       Date:  2018-06-25
  1 in total

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