| Literature DB >> 2828027 |
H Shida1, T Tochikura, T Sato, T Konno, K Hirayoshi, M Seki, Y Ito, M Hatanaka, Y Hinuma, M Sugimoto.
Abstract
The human T-lymphotropic virus type I (HTLV-I) is etiologically linked to adult T-cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV-I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A single inoculation of the recombinant virus induced antibodies to the env proteins of HTLV-I in rabbits and had a protective effect against HTLV-I infection.Entities:
Mesh:
Substances:
Year: 1987 PMID: 2828027 PMCID: PMC553794 DOI: 10.1002/j.1460-2075.1987.tb02660.x
Source DB: PubMed Journal: EMBO J ISSN: 0261-4189 Impact factor: 11.598