| Literature DB >> 28279347 |
Jeanna A Bugaytsova1, Oscar Björnham2, Yevgen A Chernov1, Pär Gideonsson1, Sara Henriksson1, Melissa Mendez1, Rolf Sjöström1, Jafar Mahdavi3, Anna Shevtsova1, Dag Ilver4, Kristof Moonens5, Macarena P Quintana-Hayashi4, Roman Moskalenko6, Christopher Aisenbrey7, Göran Bylund1, Alexej Schmidt1, Anna Åberg1, Kristoffer Brännström1, Verena Königer8, Susanne Vikström1, Lena Rakhimova9, Anders Hofer1, Johan Ögren10, Hui Liu11, Matthew D Goldman12, Jeannette M Whitmire13, Jörgen Ådén7, Justine Younson14, Charles G Kelly14, Robert H Gilman15, Abhijit Chowdhury16, Asish K Mukhopadhyay17, G Balakrish Nair18, Konstantinos S Papadakos19, Beatriz Martinez-Gonzalez19, Dionyssios N Sgouras19, Lars Engstrand20, Magnus Unemo21, Dan Danielsson21, Sebastian Suerbaum22, Stefan Oscarson23, Ludmilla A Morozova-Roche1, Anders Olofsson1, Gerhard Gröbner7, Jan Holgersson24, Anders Esberg10, Nicklas Strömberg10, Maréne Landström25, Angela M Eldridge26, Brett A Chromy26, Lori M Hansen27, Jay V Solnick28, Sara K Lindén4, Rainer Haas29, Andre Dubois11, D Scott Merrell13, Staffan Schedin2, Han Remaut5, Anna Arnqvist1, Douglas E Berg30, Thomas Borén31.
Abstract
The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease.Entities:
Keywords: Helicobacter pylori; acid responsiveness; adaptation; blood group antigen-binding adhesion; diversity; gastric acidity; gastric cancer; multimerization; polymorphism; subpopulations
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Year: 2017 PMID： 28279347 PMCID： PMC5392239 DOI： 10.1016/j.chom.2017.02.013
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023