| Literature DB >> 28278715 |
Li Wang1,2, Lan Luo2, Zhe Gao2,3, Shu-Feng Liu1, Cheng-Jun Liu1, De-Xun Ma1, Ji-Gang Chen1, Wu-Rui Cao1, Ai-Min Yin1, Jia-Wen Xu1, Song-Lei Wang1, Du-Jun Zhuo1, Bin Geng1, Sha-Sha Zhao2, Fei-Yan Wang2, Nan Yang2, Li-Xun Guan2, Zhen-Yang Gu2, Chun-Ji Gao2.
Abstract
Central nervous system lymphoma (CNSL) presents diagnostic and prognostic challenges. The aim of this meta-analysis was to evaluate the diagnostic and prognostic value of interleukin (IL)-10 in cerebrospinal fluid (CSF) for CNSL comprehensively. PubMed and Cochrane Library databases were searched through September 2016. Four studies with 212 CNSL patients and 262 control patients were included. The pooled sensitivity and specificity of CSF IL-10 for diagnosing CNSL were 81% (95% CI: 66-91%) and 97% (95% CI: 83-100%), respectively. The summary receiver operating characteristic (SROC) curve indicated that the area under the curve was 0.95 (0.93-0.97). The ROC curve based on extracted individual data showed that the optimal cutoff value was 6.88 pg/ml. Moreover, elevated CSF IL-10 was found to be associated with shorter progression-free survival (hazard ratio: 2.89, 95% CI: 1.13-7.41, p = .027). In conclusion, our meta-analysis showed that CSF IL-10 is an effective diagnostic and prognostic biomarker for CNSL.Entities:
Keywords: Cerebrospinal fluid; central nervous system lymphoma; diagnosis; interleukin-10; meta-analysis; prognosis
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Year: 2017 PMID： 28278715 DOI： 10.1080/10428194.2017.1289523
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022