Literature DB >> 28278587

Functionality of albumin-derived perfluorocarbon-based artificial oxygen carriers in the Langendorff-heart †.

Anna Wrobeln1, Klaus D Schlüter2, Jürgen Linders3, Manfred Zähres3, Christian Mayer3, Michael Kirsch1, Katja B Ferenz1.   

Abstract

The aim of this study was to prove whether albumin-derived perfluorocarbon-based nanoparticles (capsules) can operate as a novel artificial oxygen carrier in a rat Langendorff-heart perfusion model. Hearts perfused with capsules showed increased left ventricular pressure and rate pressure product compared to hearts perfused with pure Krebs-Henseleit (KH)-buffer. The capsules prevented the myocardium from functional fail when in their absence a noxious ischemia was observed. Capsules did not change rheological properties of KH-buffer and could repeatedly reload with oxygen. This albumin-derived perfluorocarbon-based artificial oxygen carrier preserved the function of rat hearts due to the transport of oxygen in a satisfactory manner. Because of these positive results, the functionality of the applied capsules should be verified in living animals.

Entities:  

Keywords:  Langendorff-heart; Perfluorocarbon-based artificial oxygen carrier; albumin; blood substitutes; nanocapsules; perfluorodecalin

Mesh：

Substances：

Year:  2017        PMID： 28278587     DOI： 10.1080/21691401.2017.1284858

Source DB:  PubMed          Journal:  Artif Cells Nanomed Biotechnol        ISSN： 2169-1401            Impact factor:   5.678


  8 in total

1.  Investigation of albumin-derived perfluorocarbon-based capsules by holographic optical trapping.

Authors:  Jannis Köhler; Jegor Ruschke; Katja Bettina Ferenz; Cemal Esen; Michael Kirsch; Andreas Ostendorf
Journal:  Biomed Opt Express       Date:  2018-01-23       Impact factor: 3.732

2.  Deciphering the Emulsification Process to Create an Albumin-Perfluorocarbon-(o/w) Nanoemulsion with High Shelf Life and Bioresistivity.

Authors:  Johannes Jaegers; Sven Haferkamp; Oliver Arnolds; Daniel Moog; Anna Wrobeln; Fabian Nocke; Miriam Cantore; Stefanie Pütz; Anne Hartwig; Rico Franzkoch; Olympia Ekaterini Psathaki; Holger Jastrow; Carsten Schauerte; Raphael Stoll; Michael Kirsch; Katja Bettina Ferenz
Journal:  Langmuir       Date:  2022-08-15       Impact factor: 4.331

3.  Optical sensor arrays designed for guided manufacture of perfluorocarbon nanoemulsions with a non-synthetic stabilizer.

Authors:  Ryan Bardsley; Graeme Gardner; Hubert M Tse; Christopher A Fraker
Journal:  Acta Biomater       Date:  2021-09-24       Impact factor: 8.947

4.  Albumin-derived perfluorocarbon-based artificial oxygen carriers can avoid hypoxic tissue damage in massive hemodilution.

Authors:  Anna Wrobeln; Johannes Jägers; Theresa Quinting; Timm Schreiber; Michael Kirsch; Joachim Fandrey; Katja B Ferenz
Journal:  Sci Rep       Date:  2020-07-20       Impact factor: 4.379

Review 5.  Perfluorocarbons for the treatment of decompression illness: how to bridge the gap between theory and practice.

Authors:  Dirk Mayer; Katja Bettina Ferenz
Journal:  Eur J Appl Physiol       Date:  2019-11-04       Impact factor: 3.078

6.  Development of a Lyophilization Process for Long-Term Storage of Albumin-Based Perfluorodecalin-Filled Artificial Oxygen Carriers.

Authors:  Sarah Hester; Katja Bettina Ferenz; Susanne Eitner; Klaus Langer
Journal:  Pharmaceutics       Date:  2021-04-20       Impact factor: 6.321

Review 7.  Current perspectives of artificial oxygen carriers as red blood cell substitutes: a review of old to cutting-edge technologies using in vitro and in vivo assessments.

Authors:  Nijaya Mohanto; Young-Joon Park; Jun-Pil Jee
Journal:  J Pharm Investig       Date:  2022-08-02

Review 8.  Perfluorocarbon-based oxygen carriers: from physics to physiology.

Authors:  Johannes Jägers; Anna Wrobeln; Katja B Ferenz
Journal:  Pflugers Arch       Date:  2020-11-03       Impact factor: 3.657
  8 in total

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