| Literature DB >> 28278578 |
Navid Ahmadi Nasab1, Hassan Hassani Kumleh2, Mojtaba Beygzadeh3, Shahram Teimourian4, Mahmood Kazemzad3.
Abstract
Mesoporous silica nanocarriers as accommodate drug molecule capsules were synthesized and capped by chitosan natural polymer. This nanocarrier acts as a pH-responsive shield to increase the solubility and improvement of anticancer properties of curcumin against U87MG glioblastoma cancer cell line. The encapsulation efficiency and drug-loading content were measured 88.1 ± 4.76% and 8.81 ± 0.47%, respectively. The curcumin release from the CS-MCM-41 was slow and sustained at low pH (42.72 ± 2.29%) compared to the environment pH (19.54 ± 1.36%) in 96 h. The MTT evaluations showed that IC50 after 72 h treatment with free curcumin and curcumin-loaded CS-MCM-41 were 15.20 and 5.21 μg/mL (p <0.05). respectively.Entities:
Keywords: Mesoporous silica; cancer therapy; chitosan; drug delivery; nanomedicine; pH sensitive
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Year: 2017 PMID： 28278578 DOI： 10.1080/21691401.2017.1290648
Source DB: PubMed Journal: Artif Cells Nanomed Biotechnol ISSN： 2169-1401 Impact factor: 5.678