Eugene G Butkowski1, Herbert F Jelinek1,2,3. 1. a School of Community Health , Charles Sturt University , Albury , Australia. 2. b School of Medicine , University of New South Wales , Sydney , Australia. 3. c Faculty of Medicine and Health Sciences , Macquarie University , Sydney , Australia.
Abstract
INTRODUCTION: The increasing prevalence of hyperglycaemia implicates a state of oxidative stress and inflammation. Traditional and emerging biomarkers associated with increasing hyperglycaemia were assessed to clarify their role they play in hyperglycaemia. RESULTS: 309 participants attending a rural diabetic screening program were categorised into control and quintile groups based upon glucose levels: 1st quintile - <4.5 mmol/L and 4th, 5th quintile - >6.1 mmol/L. Significant results were obtained for anthropometric data and biochemical markers - glucose, HbA1c and total cholesterol (P < 0.001); oxidative stress: glutathione (P < 0.001), glutathione:glutathione disulfide and 8-hydroxy-2-deoxyguanosine (P < 0.05). Interleukin -1β and inflammatory marker ratios IL-6/IL-10, IL-1β/IL-10, MCP-1/IL-10, IGF-1/IL-10 and IL-6/IL-1β were significant (P < 0.05). CONCLUSION: This study provided further evidence that inflammatory and oxidative stress biomarkers may contribute to diagnostic information associated with preclinical increases in BGL. Further we have provided a unique study in the analysis of ratios of inflammatory biomarkers and correlations with increasing BGL.
INTRODUCTION: The increasing prevalence of hyperglycaemia implicates a state of oxidative stress and inflammation. Traditional and emerging biomarkers associated with increasing hyperglycaemia were assessed to clarify their role they play in hyperglycaemia. RESULTS: 309 participants attending a rural diabetic screening program were categorised into control and quintile groups based upon glucose levels: 1st quintile - <4.5 mmol/L and 4th, 5th quintile - >6.1 mmol/L. Significant results were obtained for anthropometric data and biochemical markers - glucose, HbA1c and total cholesterol (P < 0.001); oxidative stress: glutathione (P < 0.001), glutathione:glutathione disulfide and 8-hydroxy-2-deoxyguanosine (P < 0.05). Interleukin -1β and inflammatory marker ratios IL-6/IL-10, IL-1β/IL-10, MCP-1/IL-10, IGF-1/IL-10 and IL-6/IL-1β were significant (P < 0.05). CONCLUSION: This study provided further evidence that inflammatory and oxidative stress biomarkers may contribute to diagnostic information associated with preclinical increases in BGL. Further we have provided a unique study in the analysis of ratios of inflammatory biomarkers and correlations with increasing BGL.
Entities:
Keywords:
8-hydroxy-2′-deoxyguanosine; Type 2 diabetes mellitus; body mass index; cardiovascular disease; glutathione; glutathione disulphide; impaired fasting glucose; insulin like growth factor 1; interleukin 10; interleukin 1β; interleukin-6; monocyte chemoattractant protein 1; oxidative stress; prediabetes; risk factors
Authors: Etiane Tatsch; Guilherme V Bochi; Sílvia J Piva; José A M De Carvalho; Helena Kober; Vanessa D Torbitz; Thiago Duarte; Cristiane Signor; Adriane C Coelho; Marta M M F Duarte; Greice F F S Montagner; Ivana B M Da Cruz; Rafael N Moresco Journal: Mutat Res Date: 2012-01-24 Impact factor: 2.433
Authors: Catherine C Cowie; Keith F Rust; Danita D Byrd-Holt; Edward W Gregg; Earl S Ford; Linda S Geiss; Kathleen E Bainbridge; Judith E Fradkin Journal: Diabetes Care Date: 2010-01-12 Impact factor: 19.112
Authors: Frank M Schmidt; Julia Weschenfelder; Christian Sander; Juliane Minkwitz; Julia Thormann; Tobias Chittka; Roland Mergl; Kenneth C Kirkby; Mathias Faßhauer; Michael Stumvoll; Lesca M Holdt; Daniel Teupser; Ulrich Hegerl; Hubertus Himmerich Journal: PLoS One Date: 2015-03-17 Impact factor: 3.240
Authors: Ben Schöttker; Christian Herder; Dietrich Rothenbacher; Michael Roden; Hubert Kolb; Heiko Müller; Hermann Brenner Journal: Diabetes Care Date: 2013-02-01 Impact factor: 19.112
Authors: Csilla Ari; Cem Murdun; Andrew P Koutnik; Craig R Goldhagen; Christopher Rogers; Collin Park; Sahil Bharwani; David M Diamond; Mark S Kindy; Dominic P D'Agostino; Zsolt Kovács Journal: Nutrients Date: 2019-10-01 Impact factor: 5.717