Literature DB >> 28276837

5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.

Alexander G Chamessian1,2,3, Yawar J Qadri1, Matthew Cummins1, Michele Hendrickson4, Temugin Berta5, Thomas Buchheit1, Thomas Van de Ven1.   

Abstract

Epigenetic mechanisms are increasingly implicated in chronic pain pathology. In this study, we demonstrate that the novel epigenetic mark 5-hydroxymethylcytosine (5hmC) is present in dorsal root ganglia (DRG) neurons and glia, and its levels increase following nerve injury. Furthermore, we show that the 5hmC-generating Ten-eleven translocation 1-3 (TET1-3) proteins are expressed in a cell-type specific manner in the DRG, with Tet3 displaying differential upregulation after injury, suggesting a potential role in neuropathic pain.

Entities:  

Keywords:  Chronic pain; epigenetics; neuropathic pain

Mesh：

Substances：

Year:  2017        PMID： 28276837      PMCID： PMC5818713          DOI： 10.1080/08990220.2017.1292237

Source DB:  PubMed          Journal:  Somatosens Mot Res        ISSN： 0899-0220            Impact factor:   1.111


  28 in total

1.  TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression.

Authors:  Arshan Perera; David Eisen; Mirko Wagner; Silvia K Laube; Andrea F Künzel; Susanne Koch; Jessica Steinbacher; Elisabeth Schulze; Victoria Splith; Nana Mittermeier; Markus Müller; Martin Biel; Thomas Carell; Stylianos Michalakis
Journal:  Cell Rep       Date:  2015-04-02       Impact factor: 9.423

2.  Patterns of pain: meta-analysis of microarray studies of pain.

Authors:  Michael L LaCroix-Fralish; Jean-Sebastien Austin; Felix Y Zheng; Daniel J Levitin; Jeffrey S Mogil
Journal:  Pain       Date:  2011-05-10       Impact factor: 6.961

3.  TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation.

Authors:  Garrett A Kaas; Chun Zhong; Dawn E Eason; Daniel L Ross; Raj V Vachhani; Guo-Li Ming; Jennifer R King; Hongjun Song; J David Sweatt
Journal:  Neuron       Date:  2013-09-18       Impact factor: 17.173

4.  Role of Tet1 and 5-hydroxymethylcytosine in cocaine action.

Authors:  Jian Feng; Ningyi Shao; Keith E Szulwach; Vincent Vialou; Jimmy Huynh; Chun Zhong; Thuc Le; Deveroux Ferguson; Michael E Cahill; Yujing Li; Ja Wook Koo; Efrain Ribeiro; Benoit Labonte; Benjamin M Laitman; David Estey; Victoria Stockman; Pamela Kennedy; Thomas Couroussé; Isaac Mensah; Gustavo Turecki; Kym F Faull; Guo-li Ming; Hongjun Song; Guoping Fan; Patrizia Casaccia; Li Shen; Peng Jin; Eric J Nestler
Journal:  Nat Neurosci       Date:  2015-03-16       Impact factor: 24.884

Review 5.  Epigenetic mechanisms of chronic pain.

Authors:  Giannina Descalzi; Daigo Ikegami; Toshikazu Ushijima; Eric J Nestler; Venetia Zachariou; Minoru Narita
Journal:  Trends Neurosci       Date:  2015-03-09       Impact factor: 13.837

Review 6.  Cellular and molecular mechanisms of pain.

Authors:  Allan I Basbaum; Diana M Bautista; Grégory Scherrer; David Julius
Journal:  Cell       Date:  2009-10-16       Impact factor: 41.582

7.  Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse.

Authors:  Anne-Frédérique Bourquin; Maria Süveges; Marie Pertin; Nicolas Gilliard; Sylvain Sardy; Anthony C Davison; Donat R Spahn; Isabelle Decosterd
Journal:  Pain       Date:  2006-03-20       Impact factor: 6.961

8.  A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain.

Authors:  Malin C Lagerström; Katarzyna Rogoz; Bjarke Abrahamsen; Anne-Li Lind; Caroline Olund; Casey Smith; José Alfredo Mendez; Åsa Wallén-Mackenzie; John N Wood; Klas Kullander
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-17       Impact factor: 11.205

9.  Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury.

Authors:  Michael Costigan; Katia Befort; Laurie Karchewski; Robert S Griffin; Donatella D'Urso; Andrew Allchorne; Joanne Sitarski; James W Mannion; Richard E Pratt; Clifford J Woolf
Journal:  BMC Neurosci       Date:  2002-10-25       Impact factor: 3.288

10.  5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary.

Authors:  Tarang Khare; Shraddha Pai; Karolis Koncevicius; Mrinal Pal; Edita Kriukiene; Zita Liutkeviciute; Manuel Irimia; Peixin Jia; Carolyn Ptak; Menghang Xia; Raymond Tice; Mamoru Tochigi; Solange Moréra; Anaies Nazarians; Denise Belsham; Albert H C Wong; Benjamin J Blencowe; Sun Chong Wang; Philipp Kapranov; Rafal Kustra; Viviane Labrie; Saulius Klimasauskas; Arturas Petronis
Journal:  Nat Struct Mol Biol       Date:  2012-09-09       Impact factor: 15.369
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  2 in total

1.  TET1 Overexpression Mitigates Neuropathic Pain Through Rescuing the Expression of μ-Opioid Receptor and Kv1.2 in the Primary Sensory Neurons.

Authors:  Qiang Wu; Guihua Wei; Fengtao Ji; Shushan Jia; Shaogen Wu; Xinying Guo; Long He; Zhiqiang Pan; Xuerong Miao; Qingxiang Mao; Yong Yang; Minghui Cao; Yuan-Xiang Tao
Journal:  Neurotherapeutics       Date:  2019-04       Impact factor: 7.620

Review 2.  DNA Methylation: A Target in Neuropathic Pain.

Authors:  Wei Jiang; Xuan-Yu Tan; Jia-Ming Li; Peng Yu; Ming Dong
Journal:  Front Med (Lausanne)       Date:  2022-07-07
  2 in total

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