| Literature DB >> 2827644 |
P E Gottschall1, A Uehara, S T Hoffmann, A Arimura.
Abstract
Increasing evidence suggests that factors secreted from cells of the immune system can affect endocrine function. In this report we show that the monokine, interleukin-1, inhibits follicle stimulating hormone-induced development of luteinizing hormone receptors and reduces progesterone secreted from cultured rat granulosa cells. These effects of interleukin-1 were observed in the physiological range of 10(-9) M. The ability of sex steroids to influence the immune response together with our results support the hypothesis that there is a bidirectional communication network which links the immune and reproductive endocrine systems.Entities:
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Year: 1987 PMID： 2827644 DOI： 10.1016/0006-291x(87)90396-2
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575