Qi Gao1, Yi-Xin Ren1, Yong-Ge Liu1, Lin Ma2, Xiao-Hong Gu3, Wei-Xi Zhang4, Li Liu5, Xiao-Jia Zhai6, Li Xiang7, Kun-Ling Shen8,9,10. 1. Allergy Department, Beijing Children's Hospital, Capital Medical University, Beijing, China. 2. Dermatology Department, Beijing Children's Hospital, Capital Medical University, Beijing, China. 3. Pediatric Department, People's Hospital of Wuxi City, Jiangsu Province, China. 4. Respiratory Medicine Department, Yuying Children's Hospital Affiliated to Wenzhou Medical College, Wenzhou, China. 5. Pediatric Department, the First Hospital of Jilin University, Jilin, China. 6. Pediatric Department, Xinhua Hospital Affiliated to Medicine School of Shanghai Jiaotong University, Shanghai, China. 7. National Clinical Medical Research Center for Respiratory Diseases, Beijing, China. 8. Allergy Department, Beijing Children's Hospital, Capital Medical University, Beijing, China. kunlingshen1717@163.com. 9. National Clinical Medical Research Center for Respiratory Diseases, Beijing, China. kunlingshen1717@163.com. 10. , 56 Nanlishi Road, Xicheng District, Beijing, China. kunlingshen1717@163.com.
Abstract
BACKGROUND: Allergy march refers to progression of allergic diseases from infantile food allergy to the development of asthma and allergic rhinitis (AR). Evidence come mostly from studies in European countries. This study aimed to investigate allergy march in Chinese children with infantile food protein allergy (FPA) with a special focus on the effect of different formula interventions. METHODS: From 2008 to 2010, 153 infants diagnosed with FPA were recruited in five tertiary hospitals across China. They were randomly treated with amino-acid-based formula or soy-protein-based formula for a period of 3 months. Long-term follow-up was performed when they reached early school age, using questionnaires, physical examinations, and serum-specific immunoglobulin E. RESULTS: The overall follow-up rate was 73.20%. In patients who reached their early school years, the prevalence of physician-diagnosed AR and asthma were 43.75% and 23.21%, respectively. Only 40% of the subjects remained positive for food sensitizations upon follow-up. Twenty-six subjects receiving aeroallergen screening tests in infancy all proved negative, but upon follow-up, 65.57% were sensitized to aeroallergens (P=0.005). No significant difference between the effects of amino-acid-based formula and soy-protein-based formula on children's allergy march was observed. CONCLUSIONS: A high proportion (47.32%) of Chinese infants with early allergic symptoms developed respiratory allergies by their early school years. Most food-sensitized infants outgrew their condition several years later, but then aeroallergen sensitization often occurred. Amino-acid-based formula showed no advantages over soy protein-based formula with respect to arresting the allergy march.
BACKGROUND:Allergy march refers to progression of allergic diseases from infantile food allergy to the development of asthma and allergic rhinitis (AR). Evidence come mostly from studies in European countries. This study aimed to investigate allergy march in Chinese children with infantile food protein allergy (FPA) with a special focus on the effect of different formula interventions. METHODS: From 2008 to 2010, 153 infants diagnosed with FPA were recruited in five tertiary hospitals across China. They were randomly treated with amino-acid-based formula or soy-protein-based formula for a period of 3 months. Long-term follow-up was performed when they reached early school age, using questionnaires, physical examinations, and serum-specific immunoglobulin E. RESULTS: The overall follow-up rate was 73.20%. In patients who reached their early school years, the prevalence of physician-diagnosed AR and asthma were 43.75% and 23.21%, respectively. Only 40% of the subjects remained positive for food sensitizations upon follow-up. Twenty-six subjects receiving aeroallergen screening tests in infancy all proved negative, but upon follow-up, 65.57% were sensitized to aeroallergens (P=0.005). No significant difference between the effects of amino-acid-based formula and soy-protein-based formula on children's allergy march was observed. CONCLUSIONS: A high proportion (47.32%) of Chinese infants with early allergic symptoms developed respiratory allergies by their early school years. Most food-sensitized infants outgrew their condition several years later, but then aeroallergen sensitization often occurred. Amino-acid-based formula showed no advantages over soy protein-based formula with respect to arresting the allergy march.
Authors: Susanne P Nissen; Henrik F Kjaer; Arne Høst; Jan Nielsen; Susanne Halken Journal: Pediatr Allergy Immunol Date: 2013-07-31 Impact factor: 6.377
Authors: Chris Carlsten; Helen Dimich-Ward; Alexander Ferguson; Wade Watson; Roxanne Rousseau; Anne Dybuncio; Allan Becker; Moira Chan-Yeung Journal: Ann Allergy Asthma Immunol Date: 2012-11-08 Impact factor: 6.347
Authors: Andrew S Kemp; David J Hill; Katrina J Allen; Kym Anderson; Geoffrey P Davidson; Andrew S Day; Ralph G Heine; Jane E Peake; Susan L Prescott; Albert W Shugg; John K Sinn Journal: Med J Aust Date: 2008-01-21 Impact factor: 7.738
Authors: E Lee; S H Lee; J W Kwon; Y H Kim; H J Cho; S I Yang; Y H Jung; H Y Kim; J H Seo; B J Kim; H B Kim; S Y Lee; H J Kwon; S J Hong Journal: Allergy Date: 2016-02-09 Impact factor: 13.146
Authors: H C Williams; P G Burney; R J Hay; C B Archer; M J Shipley; J J Hunter; E A Bingham; A Y Finlay; A C Pembroke; R A Graham-Brown Journal: Br J Dermatol Date: 1994-09 Impact factor: 9.302