Seyed Hasan Emami Razavi1, Mahsa Ghajarzadeh2, Alireza Abdollahi3, Ludmila Taran4, Saeed Shoar4, Ramesh Omranipour5. 1. Department of Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2. Brain and Spinal Cord Injury Research Center (BASIR), Tehran University of Medical Sciences, Tehran, Iran. 3. Department of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. 4. Department of Nephrology and Dialysis, "Dr. Carol Davila" Hospital of Nephrology, Bucharest, Romania. 5. Department of Surgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
BACKGROUND: Breast cancer is the most common cancer in women. Prostrate-specific antigen (PSA) is a marker of prostate gland malignancy which has been considered in cases with breast cancer in recent years. The goal of this study was to determine total and free PSA levels in cases with malignant and benign breast lesions. METHOD: Ninety women with histological proved malignant breast masses and 90 with benign breast masses were enrolled. Total and free PSA levels along with histological grade and conditions of vascular and perinural invasion, status of hormonal tumor receptors, immune-histo-chemistry markers recorded for all cases. Total and free PSA levels were assessed after treatment in cases with malignant masses. RESULTS: Total and free PSA levels were significantly higher in cases with malignant masses. The best cut off point for total PSA to differentiate benign and malignant masses was 0.31 and the best cut off point for free PSA to differentiate benign and malignant masses was 0.19. After treatment, mean free PSA level was significantly lower than free PSA before treatment (0.23 vs 0.3, p<0.001). CONCLUSION: Serum PSA level could be applied for differentiating benign and malignant breast masses.
BACKGROUND:Breast cancer is the most common cancer in women. Prostrate-specific antigen (PSA) is a marker of prostate gland malignancy which has been considered in cases with breast cancer in recent years. The goal of this study was to determine total and free PSA levels in cases with malignant and benign breast lesions. METHOD: Ninety women with histological proved malignant breast masses and 90 with benign breast masses were enrolled. Total and free PSA levels along with histological grade and conditions of vascular and perinural invasion, status of hormonal tumor receptors, immune-histo-chemistry markers recorded for all cases. Total and free PSA levels were assessed after treatment in cases with malignant masses. RESULTS: Total and free PSA levels were significantly higher in cases with malignant masses. The best cut off point for total PSA to differentiate benign and malignant masses was 0.31 and the best cut off point for free PSA to differentiate benign and malignant masses was 0.19. After treatment, mean free PSA level was significantly lower than free PSA before treatment (0.23 vs 0.3, p<0.001). CONCLUSION: Serum PSA level could be applied for differentiating benign and malignant breast masses.