Björn Gylling1, Robin Myte2, Jörn Schneede3, Göran Hallmans4, Jenny Häggström5, Ingegerd Johansson6, Arve Ulvik7, Per M Ueland8, Bethany Van Guelpen2, Richard Palmqvist9. 1. Departments of Medical Biosciences, Pathology. 2. Radiation Sciences, Oncology. 3. Clinical Pharmacology, Pharmacology and Clinical Neurosciences. 4. Biobank Research, Public Health and Clinical Medicine. 5. Statistics, Umeå School of Business and Economics, and. 6. Odontology, Cariology, Umeå University, Umeå, Sweden. 7. Bevital AS, Bergen, Norway; and. 8. Department of Clinical Science, University of Bergen and Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway. 9. Departments of Medical Biosciences, Pathology, richard.palmqvist@umu.se.
Abstract
Background: Higher plasma concentrations of the vitamin B-6 marker pyridoxal 5'-phosphate (PLP) have been associated with reduced colorectal cancer (CRC) risk. Inflammatory processes, including vitamin B-6 catabolism, could explain such findings.Objective: We investigated 3 biomarkers of vitamin B-6 status in relation to CRC risk.Design: This was a prospective case-control study of 613 CRC cases and 1190 matched controls nested within the Northern Sweden Health and Disease Study (n = 114,679). Participants were followed from 1985 to 2009, and the median follow-up from baseline to CRC diagnosis was 8.2 y. PLP, pyridoxal, pyridoxic acid (PA), 3-hydroxykynurenine, and xanthurenic acids (XAs) were measured in plasma with the use of liquid chromatography-tandem mass spectrometry. We calculated relative and absolute risks of CRC for PLP and the ratios 3-hydroxykynurenine:XA (HK:XA), an inverse marker of functional vitamin B-6 status, and PA:(PLP + pyridoxal) (PAr), a marker of inflammation and oxidative stress and an inverse marker of vitamin B-6 status. Results: Plasma PLP concentrations were associated with a reduced CRC risk for the third compared with the first quartile and for PLP sufficiency compared with deficiency [OR: 0.60 (95% CI: 0.44, 0.81) and OR: 0.55 (95% CI: 0.37, 0.81), respectively]. HK:XA and PAr were both associated with increased CRC risk [OR: 1.48 (95% CI: 1.08, 2.02) and OR: 1.50 (95% CI: 1.10, 2.04), respectively] for the fourth compared with the first quartile. For HK:XA and PAr, the findings were mainly observed in study participants with <10.5 y of follow-up between sampling and diagnosis.Conclusions: Vitamin B-6 deficiency as measured by plasma PLP is associated with a clear increase in CRC risk. Furthermore, our analyses of novel markers of functional vitamin B-6 status and vitamin B-6-associated oxidative stress and inflammation suggest a role in tumor progression rather than initiation.
Background: Higher plasma concentrations of the vitamin B-6 marker pyridoxal 5'-phosphate (PLP) have been associated with reduced colorectal cancer (CRC) risk. Inflammatory processes, including vitamin B-6 catabolism, could explain such findings.Objective: We investigated 3 biomarkers of vitamin B-6 status in relation to CRC risk.Design: This was a prospective case-control study of 613 CRC cases and 1190 matched controls nested within the Northern Sweden Health and Disease Study (n = 114,679). Participants were followed from 1985 to 2009, and the median follow-up from baseline to CRC diagnosis was 8.2 y. PLP, pyridoxal, pyridoxic acid (PA), 3-hydroxykynurenine, and xanthurenic acids (XAs) were measured in plasma with the use of liquid chromatography-tandem mass spectrometry. We calculated relative and absolute risks of CRC for PLP and the ratios 3-hydroxykynurenine:XA (HK:XA), an inverse marker of functional vitamin B-6 status, and PA:(PLP + pyridoxal) (PAr), a marker of inflammation and oxidative stress and an inverse marker of vitamin B-6 status. Results: Plasma PLP concentrations were associated with a reduced CRC risk for the third compared with the first quartile and for PLP sufficiency compared with deficiency [OR: 0.60 (95% CI: 0.44, 0.81) and OR: 0.55 (95% CI: 0.37, 0.81), respectively]. HK:XA and PAr were both associated with increased CRC risk [OR: 1.48 (95% CI: 1.08, 2.02) and OR: 1.50 (95% CI: 1.10, 2.04), respectively] for the fourth compared with the first quartile. For HK:XA and PAr, the findings were mainly observed in study participants with <10.5 y of follow-up between sampling and diagnosis.Conclusions: Vitamin B-6 deficiency as measured by plasma PLP is associated with a clear increase in CRC risk. Furthermore, our analyses of novel markers of functional vitamin B-6 status and vitamin B-6-associated oxidative stress and inflammation suggest a role in tumor progression rather than initiation.
Authors: Cornelia M Ulrich; Mary Playdon; Rama Kiblawi; Andreana N Holowatyj; Biljana Gigic; Stefanie Brezina; Anne J M R Geijsen; Jennifer Ose; Tengda Lin; Sheetal Hardikar; Caroline Himbert; Christy A Warby; Jürgen Böhm; Martijn J L Bours; Fränzel J B van Duijnhoven; Tanja Gumpenberger; Dieuwertje E Kok; Janna L Koole; Eline H van Roekel; Petra Schrotz-King; Arve Ulvik; Andrea Gsur; Nina Habermann; Matty P Weijenberg; Per Magne Ueland; Martin Schneider; Alexis Ulrich Journal: Br J Nutr Date: 2020-02-05 Impact factor: 3.718
Authors: Andreana N Holowatyj; Jennifer Ose; Biljana Gigic; Tengda Lin; Arve Ulvik; Anne J M R Geijsen; Stefanie Brezina; Rama Kiblawi; Eline H van Roekel; Andreas Baierl; Jürgen Böhm; Martijn J L Bours; Hermann Brenner; Stéphanie O Breukink; Jenny Chang-Claude; Johannes H W de Wilt; William M Grady; Thomas Grünberger; Tanja Gumpenberger; Esther Herpel; Michael Hoffmeister; Eric T P Keulen; Dieuwertje E Kok; Janna L Koole; Katharina Kosma; Ewout A Kouwenhoven; Gry Kvalheim; Christopher I Li; Peter Schirmacher; Petra Schrotz-King; Marie C Singer; Fränzel J B van Duijnhoven; Henk K van Halteren; Kathy Vickers; F Jeroen Vogelaar; Christy A Warby; Evertine Wesselink; Per M Ueland; Alexis B Ulrich; Martin Schneider; Nina Habermann; Ellen Kampman; Matty P Weijenberg; Andrea Gsur; Cornelia M Ulrich Journal: Am J Clin Nutr Date: 2022-08-04 Impact factor: 8.472
Authors: Nathalie Mangel; Jared B Fudge; Wilhelm Gruissem; Teresa B Fitzpatrick; Hervé Vanderschuren Journal: Front Plant Sci Date: 2022-04-04 Impact factor: 6.627
Authors: Hui Zuo; Grethe S Tell; Per M Ueland; Ottar Nygård; Stein E Vollset; Øivind Midttun; Klaus Meyer; Arve Ulvik Journal: Am J Clin Nutr Date: 2018-01-01 Impact factor: 7.045