| Literature DB >> 28274506 |
Pawan Kumar Maurya1, Lucas Bortolotto Rizzo2, Gabriela Xavier3, Priscila Farias Tempaku4, Maiara Zeni-Graiff5, Marcos L Santoro3, Diego Robles Mazzotti4, André Zugman6, Pedro Pan6, Cristiano Noto7, Michael Maes8, Elson Asevedo6, Rodrigo B Mansur9, Graccielle R Cunha6, Ary Gadelha6, Rodrigo A Bressan6, Sintia Iole Belangero3, Elisa Brietzke10.
Abstract
Telomere length attrition has been demonstrated in schizophrenia but not in individuals in ultra high risk (UHR) for psychosis. The present study aimed to compare the leukocyte telomere length (TL) between patients at UHR for psychosis and healthy controls (HC). Twenty-two participants with UHR and 88 HC were enrolled in this study. Telomere lengths were determined using a multiplex qPCR assay. After adjustment for age, sex, ethnicity, and education, patients in UHR, compared with HC groups, had shorter telomere length (RR: 0.929, p=0.031). Shorter leukocyte telomere length in UHR could represent early signs of accelerated aging in this population.Entities:
Keywords: Psychosis; Schizophrenia; Telomere; Ultra-high risk
Mesh：
Year: 2017 PMID： 28274506 DOI： 10.1016/j.euroneuro.2017.02.008
Source DB: PubMed Journal: Eur Neuropsychopharmacol ISSN： 0924-977X Impact factor: 4.600