Maria Jalbrzikowski1, Bart Larsen2, Michael N Hallquist3, William Foran4, Finnegan Calabro4, Beatriz Luna5. 1. Department of Psychiatry, University of Pittsburgh, Pittsburgh. Electronic address: mjalbrzikowski@gmail.com. 2. Department of Psychology, University of Pittsburgh, Pittsburgh. 3. Department of Psychology (MNH), Pennsylvania State University, State College, Pennsylvania. 4. Department of Psychiatry, University of Pittsburgh, Pittsburgh. 5. Department of Psychiatry, University of Pittsburgh, Pittsburgh; Department of Psychology, University of Pittsburgh, Pittsburgh; Department of Pediatrics, University of Pittsburgh, Pittsburgh.
Abstract
BACKGROUND: Connectivity between the amygdala and ventromedial prefrontal cortex (vmPFC) is compromised in multiple psychiatric disorders, many of which emerge during adolescence. To identify to what extent the deviations in amygdala-vmPFC maturation contribute to the onset of psychiatric disorders, it is essential to characterize amygdala-vmPFC connectivity changes during typical development. METHODS: Using an accelerated cohort longitudinal design (1-3 time points, 10-25 years old, n = 246), we characterized developmental changes of the amygdala-vmPFC subregion functional and structural connectivity using resting-state functional magnetic resonance imaging and diffusion-weighted imaging. RESULTS: Functional connectivity between the centromedial amygdala and rostral anterior cingulate cortex (rACC), anterior vmPFC, and subgenual cingulate significantly decreased from late childhood to early adulthood in male and female subjects. Age-associated decreases were also observed between the basolateral amygdala and the rACC. Importantly, these findings were replicated in a separate cohort (10-22 years old, n = 327). Similarly, structural connectivity, as measured by quantitative anisotropy, significantly decreased with age in the same regions. Functional connectivity between the centromedial amygdala and the rACC was associated with structural connectivity in these same regions during early adulthood (22-25 years old). Finally, a novel time-varying coefficient analysis showed that increased centromedial amygdala-rACC functional connectivity was associated with greater anxiety and depression symptoms during early adulthood, while increased structural connectivity in centromedial amygdala-anterior vmPFC white matter was associated with greater anxiety/depression during late childhood. CONCLUSIONS: Specific developmental periods of functional and structural connectivity between the amygdala and the prefrontal systems may contribute to the emergence of anxiety and depressive symptoms and may play a critical role in the emergence of psychiatric disorders in adolescence.
BACKGROUND: Connectivity between the amygdala and ventromedial prefrontal cortex (vmPFC) is compromised in multiple psychiatric disorders, many of which emerge during adolescence. To identify to what extent the deviations in amygdala-vmPFC maturation contribute to the onset of psychiatric disorders, it is essential to characterize amygdala-vmPFC connectivity changes during typical development. METHODS: Using an accelerated cohort longitudinal design (1-3 time points, 10-25 years old, n = 246), we characterized developmental changes of the amygdala-vmPFC subregion functional and structural connectivity using resting-state functional magnetic resonance imaging and diffusion-weighted imaging. RESULTS: Functional connectivity between the centromedial amygdala and rostral anterior cingulate cortex (rACC), anterior vmPFC, and subgenual cingulate significantly decreased from late childhood to early adulthood in male and female subjects. Age-associated decreases were also observed between the basolateral amygdala and the rACC. Importantly, these findings were replicated in a separate cohort (10-22 years old, n = 327). Similarly, structural connectivity, as measured by quantitative anisotropy, significantly decreased with age in the same regions. Functional connectivity between the centromedial amygdala and the rACC was associated with structural connectivity in these same regions during early adulthood (22-25 years old). Finally, a novel time-varying coefficient analysis showed that increased centromedial amygdala-rACC functional connectivity was associated with greater anxiety and depression symptoms during early adulthood, while increased structural connectivity in centromedial amygdala-anterior vmPFC white matter was associated with greater anxiety/depression during late childhood. CONCLUSIONS: Specific developmental periods of functional and structural connectivity between the amygdala and the prefrontal systems may contribute to the emergence of anxiety and depressive symptoms and may play a critical role in the emergence of psychiatric disorders in adolescence.
Authors: Mark Jenkinson; Christian F Beckmann; Timothy E J Behrens; Mark W Woolrich; Stephen M Smith Journal: Neuroimage Date: 2011-09-16 Impact factor: 6.556
Authors: Chad M Sylvester; Qiongru Yu; A Benjamin Srivastava; Scott Marek; Annie Zheng; Dimitrios Alexopoulos; Christopher D Smyser; Joshua S Shimony; Mario Ortega; Donna L Dierker; Gaurav H Patel; Steven M Nelson; Adrian W Gilmore; Kathleen B McDermott; Jeffrey J Berg; Andrew T Drysdale; Michael T Perino; Abraham Z Snyder; Ryan V Raut; Timothy O Laumann; Evan M Gordon; Deanna M Barch; Cynthia E Rogers; Deanna J Greene; Marcus E Raichle; Nico U F Dosenbach Journal: Proc Natl Acad Sci U S A Date: 2020-02-03 Impact factor: 11.205
Authors: Manpreet K Singh; Sara M Leslie; Mary Melissa Packer; Yevgeniya V Zaiko; Owen R Phillips; Elizabeth F Weisman; Danielle M Wall; Booil Jo; Natalie Rasgon Journal: Horm Behav Date: 2018-04-23 Impact factor: 3.587